MHC class II exacerbates demyelination in vivo independently of T cells.
MHC class II exacerbates demyelination in vivo independently of T cells.
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DOI：
10.1016/j.jneuroim.2008.06.034
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发表时间：
2008-10-15
影响因子：
3.3
通讯作者：
Matsushima GK
中科院分区：
文献类型：
--
作者：
Hiremath MM;Chen VS;Suzuki K;Ting JP;Matsushima GK
We have shown previously the importance of MHC class II for central nervous system remyelination; however, the function of MHC class II during cuprizone-induced demyelination has not been examined. Here, we show that I-Aβ−/− mice exhibit significantly reduced inflammation and demyelination. RAG-1−/− mice are indistinguishable from controls, indicating T cells may not play a role. The role of MHC class II depends on an intact cytoplasmic tail that leads to the production of IL-1β, TNF-α, and nitric oxide, and oligodendrocyte apoptosis. Thus, the function of MHC class II cytoplasmic tail appears to increase microglial proliferation and activation that exacerbates demyelination.
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影响因子：
56.9
作者：
GRUSBY, MJ;JOHNSON, RS;GLIMCHER, LH
通讯作者：
GLIMCHER, LH
影响因子：
6.2
作者：
FLARIS, NA;DENSMORE, TL;HICKEY, WF
通讯作者：
HICKEY, WF
影响因子：
4.4
作者：
BAKKER, DA;LUDWIN, SK
通讯作者：
LUDWIN, SK
影响因子：
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作者：
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通讯作者：
BONDADA, S
DOI：
10.1073/pnas.86.15.5933
发表时间：
1989-08-01
影响因子：
11.1
作者：
BISHOP, GA;FRELINGER, JA
通讯作者：
FRELINGER, JA