Advancement of a Positive-Pressure Dry Powder Inhaler for Children: Use of a Vertical Aerosolization Chamber and Three-Dimensional Rod Array Interface.
Advancement of a Positive-Pressure Dry Powder Inhaler for Children: Use of a Vertical Aerosolization Chamber and Three-Dimensional Rod Array Interface.
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DOI：
10.1007/s11095-020-02889-7
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发表时间：
2020-08-30
影响因子：
3.7
通讯作者：
Longest PW
中科院分区：
文献类型：
--
作者：
Farkas D;Bonasera S;Bass K;Hindle M;Longest PW
现有的干粉吸入器(DPI)对儿童的肺部输送效率非常低。这项研究的目的是改进和实验测试一种用于儿童的正压空气喷射DPI，它基于使用垂直雾化室和包含三维(3D)棒阵列结构的新的患者接口。基于喷雾干燥辅料增强生长(EEG)配方的10 mg粉末填充质量，首先评估了不同喷气喷射DPI设计的雾化性能。这些装置是在正压条件下启动的，使用的流速(10-20 L/分钟)和吸入量(750ml)与5岁儿童一致。将性能最好的设备连接到不同的喷嘴设计，以确定对气雾化的影响，并通过一个真实的儿童体外口腔-喉咙模型测试气雾剂的渗透性。新的垂直气雾室的使用产生了高质量的气雾剂形成。在喷嘴中包括3D棒阵列结构，与没有棒阵列的情况相比，气溶胶尺寸进一步减小了约20%，并有效地消散了离开装置的湍流射流。最佳病例装置和牙套组合产生<；2%的口腔-喉咙沉积损失和>；70%的肺部输送效率(基于负载剂量)。总而言之，在正压喷气式DPI的MP中使用3D棒阵列可以减少20%的气溶胶，不会显著增加MP的沉积损失，将口腔-喉咙的沉积减少6.4倍，并使肺给药效率高达基于儿科试验条件下负荷剂量的73.4%。
Available dry powder inhalers (DPIs) have very poor lung delivery efficiencies in children. The objective of this study was to advance and experimentally test a positive-pressure air-jet DPI for children based on the use of a vertical aerosolization chamber and new patient interfaces that contain a three-dimensional (3D) rod array structure. Aerosolization performance of different air-jet DPI designs was first evaluated based on a 10 mg powder fill mass of a spray-dried excipient enhanced growth (EEG) formulation. Devices were actuated with positive pressure using flow rate (10-20 L/min) and inhaled volume (750 ml) conditions consistent with a 5-year-old child. Devices with best performance were connected to different mouthpiece designs to determine the effect on aerosolization and tested for aerosol penetration through a realistic pediatric in vitro mouth-throat model. Use of the new vertical aerosolization chamber resulted in high quality aerosol formation. Inclusion of a 3D rod array structure in the mouthpiece further reduced aerosol size by approximately 20% compared to conditions without a rod array, and effectively dissipated the turbulent jet leaving the device. Best case device and mouthpiece combinations produced <2% mouth-throat depositional loss and >70% lung delivery efficiency based on loaded dose. In conclusion, use of a 3D rod array in the MP of a positive-pressure air-jet DPI was found to reduce aerosol size by 20%, not significantly increase MP depositional loss, reduce mouth-throat deposition by 6.4-fold and enable lung delivery efficiency as high as 73.4% of loaded dose based on pediatric test conditions.
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影响因子：
5.4
作者：
Lindert S;Below A;Breitkreutz J
通讯作者：
Breitkreutz J
DOI：
10.1089/jamp.2019.1540
发表时间：
2019-08-29
影响因子：
3.4
作者：
Farkas, Dale;Hindle, Michael;Longest, Worth
通讯作者：
Longest, Worth
影响因子：
5.8
作者：
Behara, Srinivas R. B.;Longest, P. Worth;Farkas, Dale R.;Hindle, Michael
通讯作者：
Hindle, Michael
DOI：
10.1136/adc.67.7_spec_no.826
发表时间：
1992-07-01
影响因子：
4.4
作者：
EVERARD, ML;STAMMERS, J;MILNER, AD
通讯作者：
MILNER, AD
影响因子：
4.5
作者：
Bass K;Longest PW
通讯作者：
Longest PW