The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei).

The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei).
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DOI:
10.1016/j.brainres.2010.12.089
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发表时间:
2011-03-24
期刊:
影响因子:
2.9
通讯作者:
Guo S
Guo S
中科院分区:
医学3区
文献类型:
--
作者:
Mueller T;Dong Z;Berberoglu MA;Guo S

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斑马鱼作为神经发生模型系统依赖于对其脑组织的正确神经解剖学理解。在这里,我们解决尚未解决的问题,关于一个可能的斑马鱼同源物的背侧苍白球司,该地区在哺乳动物中产生的isocortex。分析前斑马鱼端脑中烟碱腺嘌呤二核苷酸磷酸二磷酸酶(NADPHd)活性和小清蛋白的分布,我们表明,对以前的假设,中央(Dc)区具有自己的萌发区域的背侧增殖区。我们定义的中央(DC)区拓扑对应于其他脊椎动物(哺乳动物isocortex)的背侧苍白球司。此外,我们通过BrdU标记实验证实,后(Dp)区形成的径向迁移和同源的哺乳动物梨状皮质。基于我们的研究结果,我们提出了一个新的发展和组织模式的斑马鱼苍白球,这是一个复杂的向外向内折叠的结果。
Zebrafish as a neurogenetic model system depends on the correct neuroanatomical understanding of its brain organization. Here, we address the unresolved question regarding a possible zebrafish homologue of the dorsal pallial division, the region that in mammals gives rise to the isocortex. Analyzing the distributions of nicotine adenine dinucleotide phosphate diphorase (NADPHd) activity and parvalbumin in the anterior zebrafish telencephalon, we show that against previous assumptions the central (Dc) zone possesses its own germinative region in the dorsal proliferative zone. We define the central (Dc) zone as topologically corresponding to the dorsal pallial division of other vertebrates (mammalian isocortex). In addition, we confirm through BrdU-labeling experiments that the posterior (Dp) zone is formed by radial migration and homologous to the mammalian piriform cortex. Based on our results, we propose a new developmental and organizational model of the zebrafish pallium—one which is the result of a complex outward-inward folding.
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