Estradiol-dependent modulation of auditory processing and selectivity in songbirds.
Estradiol-dependent modulation of auditory processing and selectivity in songbirds.
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DOI：
10.1016/j.yfrne.2010.12.002
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发表时间：
2011-08
影响因子：
7.4
通讯作者：
Pinaud, Raphael
中科院分区：
文献类型：
--
作者：
Maney, Donna L.;Pinaud, Raphael
关键词：
类固醇激素雌二醇在生殖发育和行为中发挥着重要作用，并调节广泛的生理和认知过程。最近，多个研究小组的报告一致表明，雌二醇还可以强有力地调节感觉处理，特别是鸣禽中枢听觉回路的生理机能。这些研究人员发现：（1）与行为相关的听觉体验会迅速增加听觉前脑中的雌二醇水平； (2)雌二醇瞬间增强听觉神经元的反应能力和编码效率； (3) 这些变化是由大脑产生的雌二醇对抑制性神经传递强度的非基因组效应介导的； (4)雌二醇调节生化级联，诱导突触可塑性相关基因的表达。总之，这些发现确立了雌二醇作为听觉功能的中心调节剂，并且在与雌激素缺乏相关的听力病理中，除了外周器官功能障碍之外，还需要考虑基于大脑的机制。
The steroid hormone estradiol plays an important role in reproductive development and behavior and modulates a wide array of physiological and cognitive processes. Recently, reports from several research groups have converged to show that estradiol also powerfully modulates sensory processing, specifically, the physiology of central auditory circuits in songbirds. These investigators have discovered that (1) behaviorally-relevant auditory experience rapidly increases estradiol levels in the auditory forebrain; (2) estradiol instantaneously enhances the responsiveness and coding efficiency of auditory neurons; (3) these changes are mediated by a non-genomic effect of brain-generated estradiol on the strength of inhibitory neurotransmission; and (4) estradiol regulates biochemical cascades that induce the expression of genes involved in synaptic plasticity. Together, these findings have established estradiol as a central regulator of auditory function and intensified the need to consider brain-based mechanisms, in addition to peripheral organ dysfunction, in hearing pathologies associated with estrogen deficiency.
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影响因子：
3.6
作者：
Appeltants, D;Ball, GF;Balthazart, J
通讯作者：
Balthazart, J
影响因子：
1.9
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Barnes, P.;Staal, V.;Good, M. A.
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BRAUTH, SE;MCHALE, CM;DOOLING, RJ
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影响因子：
1.3
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Appeltants, D;Gentner, TQ;Ball, GF
通讯作者：
Ball, GF
影响因子：
1.7
作者：
Appeltants, D;Ball, GF;Balthazart, J
通讯作者：
Balthazart, J