Noninvasive Mapping of Ripple Onset Predicts Outcome in Epilepsy Surgery.
Noninvasive Mapping of Ripple Onset Predicts Outcome in Epilepsy Surgery.
复制标题
DOI：
10.1002/ana.26066
复制
发表时间：
2021-05
影响因子：
11.2
通讯作者：
Papadelis C
中科院分区：
文献类型：
--
作者：
Tamilia E;Matarrese MAG;Ntolkeras G;Grant PE;Madsen JR;Stufflebeam SM;Pearl PL;Papadelis C
颅内脑电图（icEEG）研究表明，药物难治性癫痫（MRE）患儿的脑间期波纹传播，这种传播的起始点（纹波起始区[ROZ]）估计癫痫发生区。目前尚不清楚我们是否可以无创性地绘制这种传播。本研究的目的是利用高密度脑电图（HD - EEG）和脑磁图（MEG）绘制纹波（纹波区[RZ]）及其传播起始（ROZ），并估计其在小儿癫痫手术中的预后价值。我们回顾性分析了28例接受icEEG和癫痫手术的MRE患儿的HD - EEG和MEG数据。利用电和磁源成像，我们估计了与冰脑电图植入相匹配的大脑位置的虚拟传感器（VSs）。我们检测了VSs上的波纹，定义了虚拟RZ和虚拟ROZ，并估计了它们与icEEG的距离。我们评估了切除虚拟RZ和虚拟ROZ对术后预后的预测价值。在HD - EEG和MEG上进行了间隔峰定位，并与波纹进行了比较。我们绘制了所有HD - EEG患者和27例（96%）MEG患者的纹波传播图谱。在绘制RZ （26-27mm, p = 0.6）或ROZ （22-24mm, p = 0.4）时，HD‐EEG和MEG与icEEG的距离没有差异。切除虚拟ROZ，但不切除虚拟RZ或峰值源，与HD - EEG （p = 0.016）和MEG （p = 0.047）的良好结果相关。HD - EEG和MEG可以绘制间隔纹波及其传播开始（虚拟ROZ）。无创绘制纹波发作可能增加癫痫手术计划和改善手术结果的儿童与MRE。Ann neurol 2021；89:911 - 925
Intracranial electroencephalographic (icEEG) studies show that interictal ripples propagate across the brain of children with medically refractory epilepsy (MRE), and the onset of this propagation (ripple onset zone [ROZ]) estimates the epileptogenic zone. It is still unknown whether we can map this propagation noninvasively. The goal of this study is to map ripples (ripple zone [RZ]) and their propagation onset (ROZ) using high‐density EEG (HD‐EEG) and magnetoencephalography (MEG), and to estimate their prognostic value in pediatric epilepsy surgery. We retrospectively analyzed simultaneous HD‐EEG and MEG data from 28 children with MRE who underwent icEEG and epilepsy surgery. Using electric and magnetic source imaging, we estimated virtual sensors (VSs) at brain locations that matched the icEEG implantation. We detected ripples on VSs, defined the virtual RZ and virtual ROZ, and estimated their distance from icEEG. We assessed the predictive value of resecting virtual RZ and virtual ROZ for postsurgical outcome. Interictal spike localization on HD‐EEG and MEG was also performed and compared with ripples. We mapped ripple propagation in all patients with HD‐EEG and in 27 (96%) patients with MEG. The distance from icEEG did not differ between HD‐EEG and MEG when mapping the RZ (26–27mm, p = 0.6) or ROZ (22–24mm, p = 0.4). Resecting the virtual ROZ, but not virtual RZ or the sources of spikes, was associated with good outcome for HD‐EEG (p = 0.016) and MEG (p = 0.047). HD‐EEG and MEG can map interictal ripples and their propagation onset (virtual ROZ). Noninvasively mapping the ripple onset may augment epilepsy surgery planning and improve surgical outcome of children with MRE. ANN NEUROL 2021;89:911–925
登录
查看更多内容
影响因子：
5.3
作者：
Cimbalnik J;Brinkmann B;Kremen V;Jurak P;Berry B;Gompel JV;Stead M;Worrell G
通讯作者：
Worrell G
影响因子：
14.5
作者：
Blanco, Justin A.;Stead, Matt;Worrell, Gregory A.
通讯作者：
Worrell, Gregory A.
DOI：
10.1016/s0013-4694(97)00142-9
发表时间：
1998-04-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Diekmann, V;Becker, W;Wollinsky, KH
通讯作者：
Wollinsky, KH
影响因子：
11.2
作者：
Frauscher, Birgit;von Ellenrieder, Nicolas;Gotman, Jean
通讯作者：
Gotman, Jean
影响因子：
2.2
作者：
Melani, Federico;Zelmann, Rina;Gotman, Jean
通讯作者：
Gotman, Jean