Woronin body-based sealing of septal pores.

Woronin body-based sealing of septal pores.
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DOI:
10.1016/j.fgb.2017.10.006
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发表时间:
2017-12
期刊:
Fungal genetics and biology : FG & B
影响因子:
--
通讯作者:
Kilaru S
Kilaru S
中科院分区:
其他
文献类型:
--
作者:
Steinberg G;Harmer NJ;Schuster M;Kilaru S

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一旦受伤,Woronin体密封丝状子囊菌中的菌丝隔膜。人们对沃宁身体移位的机制知之甚少。细胞质的被动大量流动可将Woronin小体移入隔孔。涉及Lah蛋白质的机制可能支持Woronin基于身体的密封。ATP是防止Woronin体关闭健康细胞中的毛孔所必需的。在子囊菌中,菌丝细胞被隔片隔开,允许细胞间的通讯。为了防止广泛的创伤引起的损伤,隔膜孔被过氧化物酶体衍生的Woronin体(WB)密封。支持WB运动的机制尚不清楚,但细胞质整体流动可能会将WB“冲洗”到孔中。然而,一些研究表明WB运动的受控和主动机制。事实上,在小麦病原体Zymoseptoria trivial中,细胞ATP阻止WB在未受伤细胞中的孔密封。因此,细胞似乎对WB闭合施加主动控制。在这里,我们总结了我们目前的理解,WB为基础的孔密封子囊真菌。
Upon wounding, Woronin bodies seal hyphal septa in filamentous ascomycetes. Little is known about the mechanism underpinning Woronin body translocation. Passive bulk flow of cytoplasm may move Woronin bodies into the septal pore. Mechanisms that involve Lah proteins are likely to support Woronin body based sealing. ATP is required to prevent Woronin bodies from closing pores in healthy cells. In ascomycete fungi, hyphal cells are separated by perforate septa, which allow cell-to-cell communication. To protect against extensive wound-induced damage, septal pores are sealed by peroxisome-derived Woronin bodies (WBs). The mechanism underpinning WB movement is unknown, but cytoplasmic bulk flow may “flush” WBs into the pore. However, some studies suggest a controlled and active mechanism of WB movement. Indeed, in the wheat pathogen Zymoseptoria tritici cellular ATP prevents WBs from pore sealing in unwounded cells. Thus, cells appear to exert active control over WB closure. Here, we summarize our current understanding of WB-based pore sealing in ascomycete fungi.
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