Association of SARC-F Questionnaire and Mortality in Prevalent Hemodialysis Patients.
Association of SARC-F Questionnaire and Mortality in Prevalent Hemodialysis Patients.
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DOI：
10.3390/diagnostics10110890
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发表时间：
2020-10-31
期刊：
影响因子：
--
通讯作者：
Hsu BG
中科院分区：
文献类型：
--
作者：
Lin YL;Hou JS;Lai YH;Wang CH;Kuo CH;Liou HH;Hsu BG
骨质疏松症在接受慢性血液透析的患者中很常见，这会导致不良的预后。SARC-F(行动迟缓、行走辅助、从椅子上站起来、爬楼梯、跌倒)是一种自我报告问卷，被推荐为筛查老年人石棺减少症的一种简单实用的工具。然而，关于它在慢性血液透析患者中的使用数据有限。因此，我们的目标是评估SARC-F与这些患者死亡率之间的关系。采用SARC-F问卷对271例血液透析患者进行问卷调查，平均年龄(64.4±14.3)岁。分析SARC-F与24个月随访期间死亡率之间的关系。在随访期内，40名患者(14.8%)死亡。SARC-F评分预测死亡率的判别能力为0.716(95%可信区间=0.659-0.769；p<；0.001)。以≥1评分为最佳界值，其敏感性为85.0%，特异性为47.2%，阳性预测值为21.8%，阴性预测值为94.8%。Kaplan-Meier曲线显示SARC-F≥1患者的死亡风险高于SARC-F<；1患者(p<；0.001)。此外，随着SARC-F评分的升高，患者的存活率也逐渐下降。完全校正后，≥-1与死亡率增加独立相关(危险比=2.87，95%CI=1.11-7.38；p=0.029)。总而言之，SARC-F应用于骨质疏松症筛查可预测慢性血液透析患者的死亡率。
Sarcopenia is common in patients undergoing chronic hemodialysis, which leads to poor outcomes. SARC-F (sluggishness, assistance in walking, rising from a chair, climb stairs, falls), a self-report questionnaire, is recommended as an easily applied tool for screening sarcopenia in older people. However, there are limited data regarding its use in patients undergoing chronic hemodialysis. Therefore, we aimed to evaluate the association between SARC-F and mortality in these patients. SARC-F questionnaire was applied in 271 hemodialysis patients (mean age 64.4 ± 14.3 years) at baseline. The association between SARC-F and mortality during a 24-month follow-up was analyzed. During this follow-up period, 40 patients (14.8%) died. The discriminative power of SARC-F score for predicting mortality was 0.716 (95% confidence interval (CI) = 0.659–0.769; p < 0.001). The best cut-off was a score ≥1, which provided 85.0% sensitivity, 47.2% specificity, 21.8% positive predictive value, and 94.8% negative predictive value. Kaplan–Meier curves showed that patients with SARC-F ≥ 1 exhibited a higher risk of mortality than those with SARC-F < 1 (p < 0.001). Moreover, a stepwise decline in survival with higher SARC-F scores was also observed. After full adjustments, SARC-F ≥ 1 was independently associated with increased mortality (hazard ratio = 2.87, 95% CI = 1.11–7.38; p = 0.029). In conclusion, SARC-F applied for sarcopenia screening predicted mortality in patients undergoing chronic hemodialysis.
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DOI：
10.1016/j.jamda.2017.07.006
发表时间：
2018-01-01
影响因子：
7.6
作者：
Kim, Sunyoung;Kim, Miji;Won, Chang Won
通讯作者：
Won, Chang Won
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10.1016/j.jamda.2017.05.010
发表时间：
2017-10-01
影响因子：
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作者：
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通讯作者：
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10.1016/j.jamda.2016.07.029
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影响因子：
7.6
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