Improved myo-inositol detection through Carr-Purcell PRESS: a tool for more sensitive mild cognitive impairment diagnosis.
Improved myo-inositol detection through Carr-Purcell PRESS: a tool for more sensitive mild cognitive impairment diagnosis.
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DOI：
10.1002/mrm.22749
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发表时间：
2011-06
影响因子：
3.3
通讯作者：
Zimmerman, Earl A.
中科院分区：
文献类型：
--
作者：
Hancu, Ileana;Gillen, Robert;Cowan, John;Zimmerman, Earl A.
本文介绍了一项3 T研究，比较了两种1H波谱脉冲序列，卡尔珀塞尔PRESS（CPRESS）（TE= 45 ms）和传统PRESS（TE= 35 ms）在20名正常对照（NC）和20名轻度认知障碍（MCI）受试者之间进行区分的能力。两个序列显示较高的肌肌醇（MI）和MI/N-乙酰天冬氨酸（NAA）水平在后扣带回的MCI受试者。mI和mI/NAA CPRESS测量的受试者内重复性增加（约6% vs. PRESS约9%）转化为类内变异性降低。对于NC受试者组，CPRESS的22%类内mI PRESS变异性降低至16%，CPRESS的18%类内mI/NAA PRESS变异性降低至12%。MCI受试者也观察到类似的结果。类内变异性降低导致NC和MCI受试者之间的分离改善（PRESS p=0.017，CPRESS mI/NAA p<0.0001，这是每种方法的最佳NC/MCI判别式）。mI/NAA CPRESS测量在区分NC与MCI受试者中的敏感性为75%，特异性为80%。高相关性也观察到受试者的表现在一些神经心理学测试（探测言语记忆，visuoconstructionperformance和视觉运动整合）和mI/NAA比;较高的相关系数（具有更强的统计学意义）是一贯明显的CPRESS比PRESS数据。
A 3T study is presented, comparing the ability of two 1H spectroscopy pulse sequences, Carr Purcell PRESS (CPRESS) (TE=45ms) and conventional PRESS (TE=35ms), to separate between groups of 20 normal control (NC) and 20 mild cognitive impairment (MCI) subjects. Both sequences showed higher myo-Inositol (mI) and mI/N-acetyl-aspartate (NAA) levels in the posterior cingulate gyrus of the MCI subjects. The increased intra-subject repeatability of mI and mI/NAA CPRESS measurements (~6% vs. ~9% for PRESS) translated into decreased intra-class variability. A 22% intra-class mI PRESS variability reduced to 16% for CPRESS, and an 18% intra-class mI/NAA PRESS variability reduced to 12% for CPRESS for the group of NC subjects. Similar results were observed for the MCI subjects. Decreased intra-class variability led to improved separation between NC and MCI subjects (p=0.017 for PRESS and p<0.0001 for CPRESS mI/NAA, the best NC/MCI discriminant for each method). 75% sensitivity at 80% specificity was demonstrated by mI/NAA CPRESS measurements in separating NC from MCI subjects. High correlations were also observed between subject performance on a number of neuropsychological tests (probing verbal memory, visuoconstruction performance and visual motor integration) and the mI/NAA ratio; higher correlation coefficients (with stronger statistical significance) were consistently evident for CPRESS than for PRESS data.
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影响因子：
4.4
作者：
Hancu, Ileana
通讯作者：
Hancu, Ileana
影响因子：
2.4
作者：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Bartha, Robert