A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism.
A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism.
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益生菌对自闭症学龄前儿童脑电图影响的随机对照试验。
DOI：
10.1177/13623613221082710
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发表时间：
2023-01
期刊：
影响因子：
5.2
通讯作者：
Santocchi, Elisa
中科院分区：
文献类型：
--
作者：
Billeci, Lucia;Callara, Alejandro Luis;Guiducci, Letizia;Prosperi, Margherita;Morales, Maria Aurora;Calderoni, Sara;Muratori, Filippo;Santocchi, Elisa
先前的研究表明，自闭症谱系障碍的特征是微生物-肠道-大脑轴的改变。益生菌可能会改变自闭症谱系障碍个体肠道微生物群的组成和功能，对大脑功能可能产生级联效应。在这项研究中，我们使用脑电图分析了46名自闭症谱系障碍儿童服用益生菌可能引起的大脑改变。进行了一项为期6个月的随机对照试验。在接受益生菌治疗的受试者中，我们观察到β和γ波段的额极区功率降低，相同波段的相干性增加，以及额叶不对称性的变化，这表明对典型大脑活动的修改。脑电图测量与临床和生化指标显著相关。这些发现支持了进一步研究益生菌对自闭症谱系障碍的益处的重要性，以更好地阐明益生菌补充剂与大脑活动变化之间的机制联系。本研究调查了益生菌对患有自闭症谱系障碍的学龄前儿童脑电活动的影响。孤独症是一种日益流行的疾病，其特征是巨大的个人，家庭和社会成本。虽然自闭症谱系障碍的病因是未知的，遗传和环境因素之间的相互作用是有牵连的，在改变大脑突触发生，因此，连接会聚。除了加深对这种疾病特征的静息脑电活动的了解外，这项研究还允许通过随机，双盲安慰剂对照研究以及脑电图活动与生化和临床参数之间的相关性分析益生菌6个月治疗的积极中枢作用。在接受益生菌治疗的受试者中，我们观察到β和γ波段的额极区功率降低，相同波段的相干性增加，以及额叶不对称性的变化，这表明对典型大脑活动的修改。脑电图测量与临床和生化指标显著相关。这些发现支持了进一步研究益生菌对自闭症谱系障碍的益处的重要性，以更好地阐明益生菌补充剂与大脑活动变化之间的机制联系。
Previous studies suggest that autism spectrum disorders are characterized by alterations in the microbiota–gut–brain axis. Probiotics may modify the composition and the functionality of the gut microbiota of autism spectrum disorder individuals, with possible cascading effects on brain function. In this study, we analyzed possible brain modifications induced by the administration of probiotics in 46 children with autism spectrum disorder using electroencephalography. A randomized 6-month controlled trial was performed. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. This study investigates the effects of a probiotic on preschoolers’ brain electrical activity with autism spectrum disorder. Autism is a disorder with an increasing prevalence characterized by an enormous individual, family, and social cost. Although the etiology of autism spectrum disorder is unknown, an interaction between genetic and environmental factors is implicated, converging in altered brain synaptogenesis and, therefore, connectivity. Besides deepening the knowledge on the resting brain electrical activity that characterizes this disorder, this study allows analyzing the positive central effects of a 6-month therapy with a probiotic through a randomized, double-blind placebo-controlled study and the correlations between electroencephalography activity and biochemical and clinical parameters. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity.
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