Imaging "brain strain" in youth athletes with mild traumatic brain injury during dual-task performance.
Imaging "brain strain" in youth athletes with mild traumatic brain injury during dual-task performance.
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对患有轻度脑外伤的青年运动员在执行双重任务时的“脑损伤”进行成像。
作者：
Katia J. Sinopoli;Jen;G. Wells;P. Fait;A. Ptito;Tim Taha;M. Keightley
轻度创伤性脑损伤(MTBI)是青年运动员常见的损伤原因。关于mTBI后遗症的大部分已知是从成人文献中得出的，似乎主要是那些具有持续的损伤后症状的人有持续的认知和神经异常。然而，大多数研究都采用了单一任务范式，这可能不足以揭示细微的缺陷。我们试图使用一种功能神经成像方案来检验9-15岁男性运动员双重任务表现的神经相关性。参与者包括13名在测试前三到六个月有mTBI病史的年轻人和14名典型的对照组。所有参与者在单独完成一项工作记忆任务(单任务)和同时完成一项运动任务(双任务)的同时完成一项工作记忆任务；然后比较不同组之间在执行过程中的神经活动。尽管在单一任务条件下的工作记忆表现相似，但与对照组相比，工作记忆负荷的增加导致mTBI患者关键工作记忆区域(即背外侧前额叶和顶叶皮质)的神经激活模式发生了变化。在双重任务条件下，两组之间的准确性相似，但受伤的年轻人表现得比正常发育的对照组慢，这表明只有mTBI组的速度和准确性之间存在权衡。受伤的年轻人还表现出与工作记忆和双重任务有关的大脑结构的异常招募。这些数据表明，双重任务范式可以发现患有mTBI的年轻人的功能损害，这些人没有高度症状，也没有表现出神经心理功能障碍。此外，在两种任务条件下都注意到了神经招募异常，我们认为这表明mTBI相关的干扰实现了有效的认知控制和加工资源的分配。
Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources.
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影响因子：
3.7
作者：
Verhaeghen, P;Steitz, DW;Cerella, J
通讯作者：
Cerella, J
DOI：
--
发表时间：
2004-05
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
K. Jantzen;B. Anderson;Fred L. Steinberg;J. Kelso
通讯作者：
K. Jantzen;B. Anderson;Fred L. Steinberg;J. Kelso
儿童和青少年轻度头部损伤：研究回顾（1970-1995）。
影响因子：
22.4
作者：
Satz,P;Zaucha,K;McCleary,C;Light,R;Asarnow,R;Becker,D
通讯作者：
Becker,D
儿童创伤性脑损伤的神经认知和神经影像学相关性：弥散张量成像（DTI）研究。
DOI：
10.1016/j.acn.2007.03.004
发表时间：
2007
期刊：
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
影响因子：
--
作者：
Wozniak,JeffreyR;Krach,Linda;Ward,Erin;Mueller,BryonA;Muetzel,Ryan;Schnoebelen,Sarah;Kiragu,Andrew;Lim,KelvinO
通讯作者：
Lim,KelvinO
DOI：
10.1016/s0926-6410(98)00004-4
发表时间：
1998-07-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
D'Esposito, M;Aguirre, GK;Lease, J
通讯作者：
Lease, J