The Bidirectional Association between Inflammatory Bowel Disease and Atopic Dermatitis: A Systematic Review and Meta-Analysis
The Bidirectional Association between Inflammatory Bowel Disease and Atopic Dermatitis: A Systematic Review and Meta-Analysis
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炎症性肠病与特应性皮炎之间的双向关联：系统评价和荟萃分析
DOI：
10.1159/000505290
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发表时间：
2020-01
期刊：
影响因子：
3.4
通讯作者：
Fen Wang
中科院分区：
文献类型：
--
作者：
Xiao Shi;Qi Chen;Fen Wang
背景：先前的研究表明炎症性肠病（IBD）和特应性皮炎（AD）之间存在显著相关性。然而，公布的结果仍然不一致。目的：通过系统评价和荟萃分析，探讨炎症性肠病（IBD）与阿尔茨海默病（AD）的关系。研究方法：在以下电子数据库中对1968年3月1日至2019年7月26日发表的研究进行了全面检索：PubMed、Embase、科克伦图书馆和Web of Science。方法学质量根据Newcastle-Ottawa量表评估。使用R版本3.6.1（Meta包版本4.9-7）进行数据分析。结果：共有14项研究符合探索IBD与AD之间关系的条件。IBD（风险比[RR] 1.83，95% CI 1.39-2.40）、克罗恩病（CD; RR 2.06，95% CI 1.61-2.64）和溃疡性结肠炎（UC; RR 1.66，95% CI 1.23-2.24）患者的AD合并症风险存在统计学显著性差异。与非AD受试者相比，AD患者分别有48%（p = 0.019）、44%（p = 0.002）和38%（p = 0.000）更可能罹患IBD、CD和UC。讨论：我们的证据支持IBD和AD之间存在显著的双向关联。未来的前瞻性研究是必要的，以探索潜在的机制，将它们联系起来。
Background: Previous investigations have suggested a significant association between inflammatory bowel disease (IBD) and atopic dermatitis (AD). Yet, outcomes published remain inconsistent. Objective: To explore the association between IBD and AD by a systematic review and meta-analysis. Methods: A comprehensive search of studies published from March 1, 1968, to July 26, 2019, was performed in electronic databases as follows: PubMed, Embase, Cochrane Library, and Web of Science. Methodological quality was assessed based on the Newcastle-Ottawa Scale. Data analysis was conducted using R version 3.6.1 (meta package version 4.9-7). Results: A total of 14 studies were eligible for exploring the association between IBD and AD. Statistically significant differences were found on the risk of AD comorbidity among patients with IBD (risk ratio [RR] 1.83, 95% CI 1.39–2.40), Crohn’s disease (CD; RR 2.06, 95% CI 1.61–2.64), and ulcerative colitis (UC; RR 1.66, 95% CI 1.23–2.24). Compared with non-AD subjects, patients with AD were 48% (p = 0.019), 44% (p = 0.002), and 38% (p = 0.000) more likely to exhibitIBD, CD as well as UC, respectively. Discussion: Our evidence supported a significant bidirectional association between IBD and AD. Future prospective studies are warranted to explore underlying mechanisms linking them.
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DOI：
10.1111/jdv.14157
发表时间：
2017-08
影响因子：
9.2
作者：
A. Egeberg;N. Wienholtz;G. Gislason;L. Skov;J. Thyssen
通讯作者：
A. Egeberg;N. Wienholtz;G. Gislason;L. Skov;J. Thyssen
影响因子：
1.9
作者：
Chutkan, RK
通讯作者：
Chutkan, RK
影响因子：
24.5
作者：
D. Jewell;S. Truelove
通讯作者：
D. Jewell;S. Truelove
影响因子：
2.7
作者：
Darlenski, Razvigor;Kazandjieva, Jana;Ruhr, Joachim W.
通讯作者：
Ruhr, Joachim W.
影响因子：
4.3
作者：
K. Rothfuss;E. Stange;K. Herrlinger
通讯作者：
K. Rothfuss;E. Stange;K. Herrlinger