Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae.
Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae.
复制标题
骨骼成熟显着影响负载小鼠胫骨骨内膜和骨膜区域的弹性组织特性
DOI：
10.1016/j.actbio.2015.04.020
复制
发表时间：
2015
影响因子：
9.7
通讯作者：
Willie BM
中科院分区：
文献类型：
--
作者：
Checa S;Hesse B;Roschger P;Aido M;Raum K;Duda GN;Willie BM
尽管众所周知，骨通过形成和再吸收骨基质来适应机械环境的变化，但关于机械载荷对预先存在的和新形成的骨的组织材料性质的影响知之甚少。在这项研究中，我们分析了新形成的和预先存在的组织后，两个星期的控制在体内轴向压缩负荷的年轻（10周龄）和成年（26周龄）的雌性小鼠胫骨，并与对照对侧肢体相比，通过扫描声学显微镜。此外，我们使用定量背散射电子成像来确定幼年小鼠新形成和原有骨骼内的骨矿物质密度分布。由于外部载荷，在预先存在的骨组织中未发现组织硬度或矿物质密度的显著差异。在骨内膜区域，与对照动物相比，10周和26周负荷动物的骨组织硬度降低了9%。在两个年龄组中观察到该区域的矿物沉积率增加了200%。在骨膜区域，与26周龄动物相比，10周龄动物的骨组织硬度降低和骨矿物质沉积率增加（由于载荷）是2倍。这些数据表明，在生长和骨骼成熟过程中，骨对机械负荷的反应是新骨基质的沉积，其中组织量而不是其矿物质或弹性特性受动物年龄的影响。
Although it is well known that the bone adapts to changes in the mechanical environment by forming and resorbing the bone matrix, little is known about the influence of mechanical loading on tissue material properties of the pre-existing and newly formed bone. In this study, we analyzed the newly formed and pre-existing tissue after two weeks of controlled in vivo axial compressive loading in tibia of young (10 week-old) and adult (26 week-old) female mice and compared to the control contralateral limb, by means of scanning acoustic microscopy. Additionally, we used quantitative backscattered electron imaging to determine the bone mineral density distribution within the newly formed and pre-existing bone of young mice. No significant differences were found in tissue stiffness or mineral density in the pre-existing bone tissue as a result of external loading. In the endosteal region, 10 and 26 week loaded animals showed a 9% reduction in bone tissue stiffness compared to control animals. An increase of 200% in the mineral apposition rate in this region was observed in both age groups. In the periosteal region, the reduction in bone tissue stiffness and the increase in bone mineral apposition rate as a result of loading were two times higher in the 10 compared to the 26 week old animals. These data suggest that, during growth and skeletal maturation, the response of bone to mechanical loading is a deposition of new bone matrix, where the tissue amount but not its mineral or elastic properties are influenced by animal age.
登录
查看更多内容
影响因子：
4.1
作者：
Raghavan, Mekhala;Sahar, Nadder D.;Kohn, David H.;Morris, Michael D.
通讯作者：
Morris, Michael D.
Cosmos 1887 生物卫星飞行的大鼠股骨中矿物质和基质的区域分布
DOI：
--
发表时间：
1990
期刊：
The FASEB Journal
影响因子：
--
作者：
G. Mechanic;S. Arnaud;A. Boyde;T. Bromage;P. Buckendahl;J. Elliott;E. P. Katz;G. Durnova
通讯作者：
G. Durnova
影响因子：
6.2
作者：
Järvinen, TLN;Pajamäki, I;Kannus, P
通讯作者：
Kannus, P
影响因子：
4.1
作者：
Lynch, Maureen E.;Main, Russell P.;Xu, Qian;Schmicker, Thomas L.;Schaffler, Mitchell B.;Wright, Timothy M.;van der Meulen, Marjolein C. H.
通讯作者：
van der Meulen, Marjolein C. H.
长时间体能训练对长骨特性的影响：沃尔夫定律的研究。
DOI：
--
发表时间：
1981
期刊：
Journal of Bone and Joint Surgery. American volume
影响因子：
--
作者：
S. Woo;S. Kuei;D. Amiel;M. Gómez;W. Hayes;F. White;W. Akeson
通讯作者：
W. Akeson