Defining an orbitofrontal compass: Functional and anatomical heterogeneity across anterior-posterior and medial-lateral axes.
Defining an orbitofrontal compass: Functional and anatomical heterogeneity across anterior-posterior and medial-lateral axes.
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DOI：
10.1037/bne0000442
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发表时间：
2021-04
影响因子：
1.9
通讯作者：
Panayi MC
中科院分区：
文献类型：
--
作者：
Barreiros IV;Ishii H;Walton ME;Panayi MC
眶额皮层（orbitofrontalcortex，OFC）在灵活的行为控制中起着关键作用，已成为研究的热点。然而，围绕OFC的确切理论作用存在许多争议。这些问题的一个潜在来源是比较不同研究的证据，特别是跨物种的证据，这些研究侧重于OFC内不同的特定子区域。此外，有新的证据表明，可能有功能多样性的OFC可能解释这些理论上的差异。因此，在这篇综述中，我们考虑的证据支持的功能异质性内的眶额皮层，以及它如何涉及到潜在的解剖异质性。我们强调的重要性，解剖和功能的区别，在传统定义的眶额肌亚区的内外轴，这往往是不区分的实际和历史的原因。然后，我们考虑出现的证据，甚至更细粒度的区别在这些定义的子区域沿着前后轴。这些精细的解剖学考虑揭示了眶额皮层内一种可分离但通常互补的功能模式。
The orbitofrontal cortex (OFC) plays a critical role in the flexible control of behaviors and has been the focus of increasing research interest. However, there have been a number of controversies around the exact theoretical role of the OFC. One potential source of these issues is the comparison of evidence from different studies, particularly across species, which focus on different specific sub-regions within the OFC. Furthermore, there is emerging evidence that there may be functional diversity across the OFC which may account for these theoretical differences. Therefore, in this review we consider evidence supporting functional heterogeneity within the OFC and how it relates to underlying anatomical heterogeneity. We highlight the importance of anatomical and functional distinctions within the traditionally defined OFC subregions across the medial–lateral axis, which are often not differentiated for practical and historical reasons. We then consider emerging evidence of even finer-grained distinctions within these defined subregions along the anterior–posterior axis. These fine-grained anatomical considerations reveal a pattern of dissociable, but often complementary functions within the OFC.
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影响因子：
4.7
作者：
Arinze, Ifeyinwa;Moorman, David E.
通讯作者：
Moorman, David E.
影响因子：
16.2
作者：
Chau BK;Sallet J;Papageorgiou GK;Noonan MP;Bell AH;Walton ME;Rushworth MF
通讯作者：
Rushworth MF
DOI：
10.1111/j.1749-6632.2011.06270.x
发表时间：
2011-01-01
期刊：
CRITICAL CONTRIBUTIONS OF THE ORBITOFRONTAL CORTEX TO BEHAVIOR
影响因子：
--
作者：
Balleine, Bernard W.;Leung, Beatrice K.;Ostlund, Sean B.
通讯作者：
Ostlund, Sean B.
影响因子：
2.8
作者：
Cerpa, Juan-Carlos;Marchand, Alain R.;Coutureau, Etienne
通讯作者：
Coutureau, Etienne
影响因子：
9.2
作者：
Gardner, Matthew P. H.;Conroy, Jessica C.;Schoenbaum, Geoffrey
通讯作者：
Schoenbaum, Geoffrey