Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas.
Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas.
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DOI：
10.1590/s1807-59322010001200009
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Carvalho JP
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文献类型：
--
作者：
Carvalho FM;Zaganelli FL;Almeida BG;Goes JC;Baracat EC;Carvalho JP
探讨podoplanin在早期子宫颈癌瘤内间质及肿瘤细胞表达的临床病理意义。2000年至2007年间，共有143例临床I期和IIA期宫颈癌患者接受了手术治疗。回顾性回顾了与这些病例相关的临床病理资料和载玻片。使用单克隆抗体D2‐40免疫检测组织微阵列块组织学切片中podoplanin的表达。肿瘤细胞中有31/143（21.6%）表达podoplanin，其中29/31（93.5%）诊断为鳞状癌。对于所有的病例，在肿瘤巢的增殖边缘观察到最强的podoplanin表达信号。淋巴结阳性病例的podoplanin阳性表达率低于淋巴结阴性病例（分别为18.9%和22.6%）。死亡病例中podoplanin阳性表达率分别为10.5%和21.6%。在27/143（18.8%）的病例中，肿瘤间质成纤维细胞中检测到podoplanin表达，且其表达与患者年龄、临床分期、肿瘤大小、组织学类型、浸润深度或血管累及无关。此外，podoplanin在瘤内间质成纤维细胞中的表达与淋巴结转移仅呈负相关。瘤内间质成纤维细胞阴性的死亡病例较多（分别为15.5%和3.7%），但差异不显著。这些初步结果表明，podoplanin可能在宿主-肿瘤相互作用中起作用，因此可能代表了宫颈鳞状癌的有利预后因素。
To investigate the clinicopathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer. A total of 143 patients with clinical stage I and IIA uterine cervical carcinomas underwent surgery between 2000 and 2007. Clinicopathological data and slides associated with these cases were retrospectively reviewed. Immunodetection of podoplanin expression in histologic sections of tissue microarray blocks was performed using the monoclonal antibody D2‐40. Expression of podoplanin was detected in neoplastic cells in 31/143 (21.6%) cases, with 29/31 (93.5%) of these cases diagnosed as squamous carcinoma. For all of the cases examined, the strongest signal for podoplanin expression was observed at the proliferating edge of the tumor nests. The rate of positive podoplanin expression for node‐positive cases was lower than that of node‐negative (18.9% vs. 22.6%, respectively). Furthermore, the rate of positive podoplanin expression in fatal cases was 10.5% vs. 21.6%, respectively. In 27/143 (18.8%) cases, podoplanin expression was detected in fibroblasts of the intratumoral stroma, and this expression did not correlate with patient age, clinical stage, tumor size, histologic type, depth of infiltration, or vascular involvement. Moreover, expression of podoplanin in intratumoral stroma fibroblasts was only negatively associated with nodal metastasis. A greater number of fatal cases was observed among negative intratumoral stroma fibroblasts (15.5% vs. 3.7%, respectively), although this difference was not significant. These preliminary results suggest that podoplanin may have a role in host‐tumor interactions and, as a result, may represent a favorable prognostic factor for squamous cervical carcinomas.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
DOI：
10.1083/jcb.200601018
发表时间：
2006-03-27
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lee JM;Dedhar S;Kalluri R;Thompson EW
通讯作者：
Thompson EW
影响因子：
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作者：
Dumoff, KL;Chu, C;Acs, G
通讯作者：
Acs, G
影响因子：
50.3
作者：
Wicki, A;Lehembre, F;Christofori, G
通讯作者：
Christofori, G