Development of a clinically relevant animal model for the talar osteonecrosis in sheep.
Development of a clinically relevant animal model for the talar osteonecrosis in sheep.
复制标题
绵羊距骨骨坏死临床相关动物模型的开发
DOI：
10.7150/ijms.4882
复制
发表时间：
2012
影响因子：
3.6
通讯作者：
Guo Z
中科院分区：
文献类型：
--
作者：
Yuan CF;Wang JL;Zhang YQ;Li XK;Li Y;Wu SH;Zhang ZY;Guo Z
There are a lot of reports and reviews about osteonecrosis of the talus (ONT), yet reports about the animal model of ONT to evaluate proper therapeutic approaches are rarely heard. In our study, a novel animal model was established. Pure ethanol was injected into the cancellous bone of sheep's talus. Macroscopic observation, X-ray, CT and histology were performed at two, four, 12 and 24 weeks postoperatively. It was revealed that the trabeculae of talar head began to change their structure after two weeks postoperatively compared to the normal talus. The ONT was obvious at the end of the fourth week, and their outstanding feature was the damage of trabeculae bone and formation of cavities. CT scans and pathological changes of the subjects all showed characteristics of the early stage of osteonecrosis, also the sections of the specimens confirmed necrosis of tali. By 12 weeks, the phenomenon of necrosis still existed but fibrous tissue proliferated prominently and bone reconstruction appeared in certain area. Most specimens (3/4) got late stage necrosis which presented as synarthrosis in X-ray and mass proliferation of fibrous tissue in histology at the end of 24 weeks. The novel animal model of ONT was successful, and it is inclined to deteriorate without any intervention. The study provides us a new way to evaluate various treatments on ONT in laboratory, which may eventually pave way to clinical applications.
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DOI：
10.1016/s0895-3988(08)60060-4
发表时间：
2008-10
期刊：
Biomedical and environmental sciences : BES
影响因子：
--
作者：
Wen Q;Ma L;Chen YP;Yang L;Luo W;Wang XN
通讯作者：
Wang XN
影响因子：
2.4
作者：
Manggold, J;Sergi, C;Simank, HG
通讯作者：
Simank, HG
影响因子：
7
作者：
Wan, L.;de Asla, R. J.;Li, G.
通讯作者：
Li, G.
微波加热组织工程骨修复新型股骨头坏死动物模型
影响因子：
2.7
作者：
Li, Yanlin;Han, Rui;Wei, Lei
通讯作者：
Wei, Lei
DOI：
10.2106/00004623-199804000-00009
发表时间：
1998-04-01
影响因子：
5.3
作者：
Delanois, RE;Mont, MA;Hungerford, DS
通讯作者：
Hungerford, DS