Pierreiones A-D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from Antheroporum pierrei.
Pierreiones A-D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from Antheroporum pierrei.
复制标题
DOI：
10.1021/np100763p
复制
发表时间：
2011-04-25
影响因子：
5.1
通讯作者：
Gunatilaka AA
中科院分区：
文献类型：
--
作者：
Gao S;Xu YM;Valeriote FA;Gunatilaka AA
Bioassay-guided fractionation of a solid tumor selective extract of the leaves and twigs of Antheroporum pierrei acquired from the U.S. National Cancer Institute extract repository afforded four new pyranoisoflavones, pierreiones A–D (1 – 4), together with rotenone (5), 12a-hydroxyrotenone (6), and tephrosin (7). The structures of all new compounds were determined on the basis of their spectroscopic data, and the absolute configuration of 1 was assigned with the help of 1H NMR analysis of its Mosher's ester derivatives. Compounds 1, and 5–7 accounted for the majority of the biological activity in terms of either cytotoxicity and/or selective toxicity to solid tumor cell lines. Pierreiones A (1) and B (2) demonstrated solid tumor selectivity with minimal cytotoxicity while pierreione C (3) exhibited no activity.
登录
查看更多内容
影响因子：
3.5
作者：
Yin, S;Fan, CQ;Yue, JM
通讯作者：
Yue, JM
影响因子：
3.5
作者：
Matsuda, Hisashi;Yoshida, Kazutoshi;Yoshikawa, Masayuki
通讯作者：
Yoshikawa, Masayuki
影响因子：
3.8
作者：
Nkengfack, AE;Azebaze, AGB;van Heerden, FR
通讯作者：
van Heerden, FR
影响因子：
3.8
作者：
Mahabusarakam, W;Deachathai, S;Taylor, WC
通讯作者：
Taylor, WC
影响因子：
2
作者：
MURTHY, MSR;RAO, EV;WARD, RS
通讯作者：
WARD, RS