Spectroscopic Imaging of Deep Tissue through Photoacoustic Detection of Molecular Vibration.
Spectroscopic Imaging of Deep Tissue through Photoacoustic Detection of Molecular Vibration.
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DOI:
10.1021/jz400559a
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发表时间:
2013-07-03
期刊:
影响因子:
--
通讯作者:
Cheng JX
中科院分区:
文献类型:
--
作者:
Wang P;Rajian JR;Cheng JX
The quantized vibration of chemical bonds provides a way of imaging target molecules in a complex tissue environment. Photoacoustic detection of harmonic vibrational transitions provides an approach to visualize tissue content beyond the ballistic photon regime. This method involves pulsed laser excitation of overtone transitions in target molecules inside a tissue. Fast relaxation of the vibrational energy into heat results in a local temperature rise on the order of mK and a subsequent generation of acoustic waves detectable with an ultrasonic transducer. In this perspective, we review recent advances that demonstrate the advantages of vibration-based photoacoustic imaging and illustrate its potential in diagnosing cardiovascular plaques. An outlook into future development of vibrational photoacoustic endoscopy and tomography is provided.
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