Altered anterior cingulate neurochemistry in emerging adult binge drinkers with a history of alcohol-induced blackouts.
Altered anterior cingulate neurochemistry in emerging adult binge drinkers with a history of alcohol-induced blackouts.
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DOI：
10.1111/acer.12346
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Sneider JT
中科院分区：
文献类型：
--
作者：
Silveri MM;Cohen-Gilbert J;Crowley DJ;Rosso IM;Jensen JE;Sneider JT
Binge alcohol consumption is associated with multiple neurobiological consequences, including altered neurophysiology, brain structure and functional activation. Magnetic resonance spectroscopy (MRS) studies have demonstrated neurochemical alterations in the frontal lobe of alcohol users, although most studies focused on older, alcohol dependent subjects. In this study, neurochemical data were acquired using MRS at 4T from emerging adults (18–24 years old) who were binge alcohol drinkers (BD, n=23) or light drinkers (LD, n=31). Since binge drinking is also associated with increased prevalence of experiencing an alcohol-induced blackout, BD were stratified into alcohol-induced blackout (BDBO) and non-blackout groups (BDN). Overall, BD had significantly lower gamma amino-butyric acid (GABA) and N-acetyl-aspartate (NAA) in the anterior cingulate cortex (ACC) than LD. When stratified by blackout history, BDBO also had lower ACC glutamate (Glu) than LD. No group differences in MRS metabolites were observed in the parietal-occipital cortex. Lower ACC GABA and glutamate remained significant after accounting for lower grey matter content in BD, however NAA differences were no longer evident. In addition, low ACC GABA levels were associated with greater alcohol use consequences, and worse response inhibition and attention/mental flexibility in BD. These data indicate that binge drinking affects frontal lobe neurochemistry, more so in those who had experienced an alcohol-induced blackout. Characterization of the neurochemical profiles associated with binge alcohol consumption and blackout history may help identify unique risk factors for the later manifestation of alcohol abuse and dependence, in young individuals who are heavy, frequent drinkers, but who do not meet the criteria for alcohol use disorders.
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影响因子：
2.9
作者：
Jensen, J. Eric;Licata, Stephanie C.;Renshaw, Perry F.
通讯作者：
Renshaw, Perry F.
DOI：
10.15288/jsa.2005.66.130
发表时间：
2005-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Hustad, JTP;Carey, KB
通讯作者：
Carey, KB
DOI：
10.1007/7854_2011_131
发表时间：
2013-01-01
期刊：
BEHAVIORAL NEUROBIOLOGY OF ALCOHOL ADDICTION
影响因子：
--
作者：
Meyerhoff, Dieter J.;Durazzo, Timothy C.;Ende, Gabriele
通讯作者：
Ende, Gabriele
影响因子：
2.2
作者：
Arnett, JJ
通讯作者：
Arnett, JJ
影响因子：
10.6
作者：
Gomez, Rosane;Behar, Kevin L.;Watzl, June;Weinzimer, Stuart A.;Gulanski, Barbara;Sanacora, Gerard;Koretski, Julia;Guidone, Elizabeth;Jiang, Lihong;Petrakis, Ismene L.;Pittman, Brian;Krystal, John H.;Mason, Graeme F.
通讯作者：
Mason, Graeme F.