Oxytocin and Rodent Models of Addiction.
Oxytocin and Rodent Models of Addiction.
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DOI：
10.1016/bs.irn.2018.07.007
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发表时间：
2018
影响因子：
--
通讯作者：
Reichel CM
中科院分区：
文献类型：
--
作者：
Leong KC;Cox S;King C;Becker H;Reichel CM
人们对使用催产素治疗毒瘾的兴趣始于 40 多年前。催产素以其在分娩、哺乳和伴侣关系中的作用而闻名，它还具有抗焦虑特性，减少免疫和炎症反应，并在学习和记忆中发挥作用。在本章中，通过强调在当前成瘾、复发或渴望的临床前动物模型中使用催产素的研究结果来描述催产素对成瘾过程的影响。首先，我们提供内源性催产素系统的简要背景，然后描述用于研究成瘾的行为模型，包括吸毒和寻求药物的模型。然后，我们回顾了最近的临床前研究，这些研究从行为和神经生物学的角度使用催产素作为成瘾周期多个阶段的治疗干预措施。这些模型涵盖了成瘾周期的整个范围，包括吸毒的获得和维持、戒毒期间的戒断和渴望，以及最终的复发。然后，我们提出了关于催产素如何与药物和社会奖励相互作用的几种理论，并提出了特定催产素受体定位如何有助于催产素作为成瘾治疗剂的功效的机制解释。
Interest for the use of oxytocin as a treatment for addiction began over 40years ago. Better known for its roles in parturition, lactation and pair bonding, oxytocin also has anxiolytic properties, reduces immune and inflammatory responses, and has a role in learning and memory. In this chapter, oxytocin effects on addiction processes are described by highlighting research findings that have used oxytocin within current preclinical animal models of addiction, relapse, or craving. First, we provide a brief background of the endogenous oxytocin system followed by descriptions of the behavioral models used to study addiction, including models of drug taking and seeking. Then we review recent preclinical studies that have used oxytocin as a therapeutic intervention throughout multiple stages of the addiction cycle from a behavioral and neurobiological perspective. These models encompass the entire range of the addiction cycle including acquisition and maintenance of drug taking, withdrawal and craving during periods of drug abstinence, and ultimately relapse. We then posit several theories about how oxytocin interacts with both drug and social reward, as well as presenting a mechanistic account of how specific oxytocin receptor localization may contribute to oxytocin’s efficacy as an addiction therapeutic.
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影响因子：
4.7
作者：
BOHUS, B;URBAN, I;DEWIED, D
通讯作者：
DEWIED, D
影响因子：
3.7
作者：
Bowen MT;Carson DS;Spiro A;Arnold JC;McGregor IS
通讯作者：
McGregor IS
DOI：
10.1073/pnas.1416900112
发表时间：
2015-03-10
影响因子：
11.1
作者：
Bowen, Michael T.;Peters, Sebastian T.;McGregor, Iain S.
通讯作者：
McGregor, Iain S.
DOI：
10.1017/s1461145714000388
发表时间：
2014-10-01
影响因子：
4.8
作者：
Bowen, Michael T.;McGregor, Iain S.
通讯作者：
McGregor, Iain S.
DOI：
10.1016/j.pbb.2017.08.012
发表时间：
2017-10
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Bernheim A;Leong KC;Berini C;Reichel CM
通讯作者：
Reichel CM