Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans?
Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans?
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DOI：
10.1080/07315724.2020.1789518
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发表时间：
2020-11
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
早期报告表明，COVID-19感染的严重程度与世界各地人群中普遍存在的25-羟基维生素D缺乏症之间存在关联。维生素D缺乏症在非洲裔美国人社区中极为常见，与以白人为主的社区相比，非洲裔美国人的COVID-19感染率高出三倍，死亡率高出近六倍。COVID-19感染主要影响肺部和呼吸道。先前的报告将25-羟基维生素D缺乏与亚临床间质性肺病联系起来。AA有细胞谷胱甘肽（GSH）水平降低的风险，GSH缺乏会从表观遗传上损害VD生物合成途径基因。与单独补充维生素D相比，在小鼠研究中，维生素D和l -半胱氨酸（GSH前体）的联合补充在提高细胞/组织水平的GSH和vd调节基因水平、增加25（OH）维生素D水平和降低血液中的炎症生物标志物方面表现出更好的效果。我们建议需要进行随机临床试验，以研究联合补充抗炎抗氧化剂、维生素D和l -半胱氨酸在纠正25(OH)VD缺乏症和预防“细胞因子风暴”（感染COVID-19的最严重后果之一）方面的潜力，从而预防COVID-19感染在易感AA人群中的不良临床影响。
Early reports indicate an association between the severity of the COVID-19 infection and the widespread 25-hydroxy vitamin D deficiency known to exist in populations around the world. Vitamin D deficiency is extremely common among African American (AA) communities, where the COVID-19 infection rate is three-fold higher, and the mortality rate nearly six-fold higher, compared with rates in predominantly white communities. COVID-19 infection primarily affects the lungs and airways. Previous reports have linked 25-hydroxy vitamin D deficiency with subclinical interstitial lung disease. AA are at risk for lower cellular glutathione (GSH) levels and GSH deficiency epigenetically impairs VD biosynthesis pathway genes. Compared with vitamin D alone, co-supplementation of vitamin D and L-cysteine (a GSH precursor) showed a better efficacy in improving levels of GSH and VD-regulatory genes at the cellular/tissue level, and increasing 25(OH) vitamin D levels and reducing inflammation biomarkers in the blood in mice studies. We propose that randomized clinical trials are needed to examine the potential of co-supplementation with anti-inflammatory antioxidants, vitamin D and L-cysteine in correcting the 25(OH)VD deficiency and preventing the ‘cytokine storm,’ one of the most severe consequences of infection with COVID-19, thereby preventing the adverse clinical effects of COVID-19 infection in the vulnerable AA population.
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作者：
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发表时间：
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影响因子：
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