RNAs as Regulators of Cellular Matchmaking.
RNAs as Regulators of Cellular Matchmaking.
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DOI：
10.3389/fmolb.2021.634146
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发表时间：
2021
影响因子：
5
通讯作者：
Buchan JR
中科院分区：
文献类型：
--
作者：
Fernandes N;Buchan JR
RNA 分子越来越多地被认为可以促进或阻碍蛋白质和核酸的相互作用，充当所谓的支架或诱饵。长非编码RNA通常与这些作用有关，特别是在核过程的调节中，包括染色体拓扑、染色质状态和基因转录的调节以及核生物分子凝聚体（例如副斑斑）的组装。最近，人们对细胞质 RNA 支架和诱饵的认识开始增强，包括鉴定 mRNA 的非编码区域，这些区域也可以以类似支架的方式发挥作用，调节新生翻译蛋白的相互作用。总的来说，细胞质 RNA 支架和诱饵现在涉及 mRNA 翻译、衰变、蛋白质定位、蛋白质降解和细胞质生物分子凝聚物（如 P 体）组装等过程。在这里，我们回顾了细胞核和细胞质中 RNA 支架和诱饵的例子，说明了共同主题、RNA 对这些角色的适用性，以及识别和更好地理解 RNA 支架和诱饵功能的未来挑战。
RNA molecules are increasingly being identified as facilitating or impeding the interaction of proteins and nucleic acids, serving as so-called scaffolds or decoys. Long non-coding RNAs have been commonly implicated in such roles, particularly in the regulation of nuclear processes including chromosome topology, regulation of chromatin state and gene transcription, and assembly of nuclear biomolecular condensates such as paraspeckles. Recently, an increased awareness of cytoplasmic RNA scaffolds and decoys has begun to emerge, including the identification of non-coding regions of mRNAs that can also function in a scaffold-like manner to regulate interactions of nascently translated proteins. Collectively, cytoplasmic RNA scaffolds and decoys are now implicated in processes such as mRNA translation, decay, protein localization, protein degradation and assembly of cytoplasmic biomolecular condensates such as P-bodies. Here, we review examples of RNA scaffolds and decoys in both the nucleus and cytoplasm, illustrating common themes, the suitability of RNA to such roles, and future challenges in identifying and better understanding RNA scaffolding and decoy functions.
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DOI：
10.1126/science.aal2512
发表时间：
2017-06-09
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
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DOI：
10.1098/rstb.2017.0021
发表时间：
2017-11-05
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.bbcan.2015.07.001
发表时间：
2015-08
期刊：
Biochimica et biophysica acta
影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.1509317112
发表时间：
2015-09-22
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
19
作者：
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通讯作者：
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