Inositol and vitamin D may naturally protect human reproduction and women undergoing assisted reproduction from Covid-19 risk.
Inositol and vitamin D may naturally protect human reproduction and women undergoing assisted reproduction from Covid-19 risk.
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DOI：
10.1016/j.jri.2021.103271
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发表时间：
2021-04
影响因子：
3.4
通讯作者：
Aragona C
中科院分区：
文献类型：
--
作者：
Bezerra Espinola MS;Bertelli M;Bizzarri M;Unfer V;Laganà AS;Visconti B;Aragona C
于二零一九年年底，新型冠状病毒在武汉市被发现，随后COVID-19在世界其他地区迅速蔓延。孕妇是堕胎率增加的一个风险类别，最近证实了对新生儿有不良影响的垂直传播。科学界正在努力寻找一种有效的治疗方法来对抗疟疾。今天，有许多治疗建议，但没有一个能有效地对抗感染。此外，这些化合物中的许多显示出重要的副作用，而不是证明它们的使用是合理的。科学文献报道了通过白细胞介素-6激活的免疫系统过度反应。在这方面，控制免疫系统的可能性代表了对抗COVID-19肺炎的可能策略。维生素D缺乏会增加对急性病毒性呼吸道感染的易感性。此外，维生素D似乎通过调节细胞因子的活化和释放参与宿主对不同病毒种类的保护。肌醇通过磷脂酰肌醇-3-激酶（PI 3 K）途径下调IL-6的表达。此外，肌醇是表面活性剂中磷脂的前体，其用于诱导婴儿的表面活性剂合成以治疗呼吸窘迫综合征（RDS）。本综述旨在总结关于孕妇感染COVID-19的证据，并鼓励科学界研究维生素D和肌醇的使用，这可能是孕妇或接受辅助生殖技术（ART）的妇女的一种可能的预防性治疗。
In late 2019, the new Coronavirus has been identified in the city of Wuhan then COVID-19 spreads like wildfire in the rest of the world. Pregnant women represent a risk category for increased abortion rates and vertical transmission with adverse events on the newborns has been recently confirmed. The scientific world is struggling for finding an effective cure for counteracting symptomatology. Today, there are many therapeutic proposes but none of them can effectively counteract the infection. Moreover, many of these compounds show important side effects not justifying their use. Scientific literature reports an immune system over-reaction through interleukins-6 activation. In this regard, the possibility to control the immune system represents a possible strategy for counteracting the onset of COVID-19 symptomatology. Vitamin D deficiency shows increased susceptibility to acute viral respiratory infections. Moreover, Vitamin D seems involved in host protection from different virus species by modulating activation and release of cytokines. Myo-inositol down-regulates the expression of IL-6 by phosphatidyl-inositol-3-kinase (PI3K) pathway. Furthermore, myo-inositol is the precursor of phospholipids in the surfactant and it is applied for inducing surfactant synthesis in infants for treating respiratory distress syndrome (RDS). This review aims to summarize the evidence about COVID-19 infection in pregnant women and to encourage the scientific community to investigate the use of Vitamin D and Myo-inositol which could represent a possible preventive treatment for pregnant women or women undergoing assisted reproductive technologies (ART).
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影响因子：
--
作者：
Hansdottir, Sif;Monick, Martha M.
通讯作者：
Monick, Martha M.
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.23750/abm.v91i1.9402
发表时间：
2020-03-19
期刊：
Acta bio-medica : Atenei Parmensis
影响因子：
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作者：
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影响因子：
168.9
作者：
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通讯作者：
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