Histopathologic diagnosis of endometrial precancers: Updates and future directions.
Histopathologic diagnosis of endometrial precancers: Updates and future directions.
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子宫内膜癌前病变的组织学诊断：更新和未来方向。
DOI：
10.1053/j.semdp.2021.12.001
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发表时间：
2022-05
影响因子：
2.3
通讯作者：
中科院分区：
文献类型：
--
作者：
早期发现子宫内膜癌，特别是其癌前病变，仍然是患者管理和寻求降低子宫内膜癌死亡率的关键和不断发展的问题。由于许多因素，如标本破碎，内源性或外源性激素的混杂影响，以及可变或重叠的组织学特征，识别真正的子宫内膜癌前病变及其与良性模拟物的可靠区分仍然是诊断病理学中最具挑战性的领域之一。同时，子宫内膜癌前病变的诊断，或子宫内膜活检中存在可疑但亚诊断特征，可能导致长期的临床随访，包括多次患者访视和连续子宫内膜取样，强调了准确诊断的必要性。由于对形态学标准、子宫内膜癌及其前体的分子遗传学、新型生物标志物的验证及其在面板中的使用以及最近的数字图像分析等方法的系统研究，我们对子宫内膜癌前体及其诊断的理解有所提高。虽然癌前病变的类和非类胶质细胞癌将审查，重点将放在前者。我们回顾了这些进展及其与子宫内膜癌前病变组织病理学诊断的相关性，以及最近更新的2020年世界卫生组织（WHO）女性生殖器肿瘤分类。
Early detection of endometrial cancer, especially its precancers, remains a critical and evolving issue in patient management and the quest to decrease mortality due to endometrial cancer. Due to many factors such as specimen fragmentation, the confounding influence of endogenous or exogenous hormones, and variable or overlapping histologic features, identification of bona fide endometrial precancers and their reliable discrimination from benign mimics remains one of the most challenging areas in diagnostic pathology. At the same time, the diagnosis of endometrial precancer, or the presence of suspicious but subdiagnostic features in an endometrial biopsy, can lead to long clinical follow-up with multiple patient visits and serial endometrial sampling, emphasizing the need for accurate diagnosis. Our understanding of endometrial precancers and their diagnosis has improved due to systematic investigations into morphologic criteria, the molecular genetics of endometrial cancer and their precursors, the validation of novel biomarkers and their use in panels, and more recent methods such digital image analysis. Although precancers for both endometrioid and non-endometrioid carcinomas will be reviewed, emphasis will be placed on the former. We review these advances and their relevance to the histopathologic diagnosis of endometrial precancers, and the recently updated 2020 World Health Organization (WHO) Classification of Female Genital Tumors.
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影响因子：
5.6
作者：
Allison, Kimberly H.;Reed, Susan D.;Garcia, Rochelle L.
通讯作者：
Garcia, Rochelle L.
DOI：
10.1016/0028-2243(77)90069-7
发表时间：
1977-01-01
影响因子：
2.6
作者：
DIEGENBACH, PC;BAAK, JPA
通讯作者：
BAAK, JPA
子宫内膜腺发育不良（EMGD）：II型子宫内膜癌的形态和生物学上独特的假定前体病变。
影响因子：
2.6
作者：
Fadare, Oluwole;Zheng, Wenxin
通讯作者：
Zheng, Wenxin
DOI：
10.1002/path.5628
发表时间：
2021-05
期刊：
The Journal of pathology
影响因子：
--
作者：
Aguilar M;Zhang H;Zhang M;Cantarell B;Sahoo SS;Li HD;Cuevas IC;Lea J;Miller DS;Chen H;Zheng W;Gagan J;Lucas E;Castrillon DH
通讯作者：
Castrillon DH
DOI：
10.1097/pgp.0000000000000583
发表时间：
2020-03-01
影响因子：
2.4
作者：
Costigan, Danielle C.;Dong, Fei;Howitt, Brooke E.
通讯作者：
Howitt, Brooke E.