Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals.
Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals.
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DOI：
10.1186/1471-2148-8-46
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发表时间：
2008-02-12
影响因子：
3.4
通讯作者：
Karn RC
中科院分区：
文献类型：
--
作者：
Laukaitis CM;Heger A;Blakley TD;Munclinger P;Ponting CP;Karn RC
草案小鼠（小家鼠）基因组序列显示了一个意想不到的增殖基因重复编码一个家庭的分泌珠蛋白蛋白，包括雄激素结合蛋白（ABP）的α，β和γ亚基。对14个α-like（Abpa）和13个β-或γ-like（Abpbg）未破坏基因序列的进一步研究揭示了发育阶段、性别和组织特异性表达的丰富多样性。尽管有这些研究，我们对这个基因家族的进化的理解仍然是不完整的。这些问题来自于小鼠基因组初始组装的不完善，以及缺乏其他啮齿动物和哺乳动物基因家族结构的信息。在这里，我们询问最新的“成品”小鼠（小家鼠）的基因组序列组装表明，Abp基因库，事实上，是以前报道的两倍大，有30个Abpa和34个Abpbg基因和假基因。所有这些都是从最后一个与大鼠（Rattus norvegicus）共同的祖先开始出现的。然后，我们通过对小鼠属内物种的同源物进行测序，证明这种基因复制的爆发发生在最近，在过去的七百万年内。最后，我们调查了来自整个哺乳动物进化枝的基因组中的Abp直向同源物，并表明爆发的Abp基因重复并不是鼠啮齿动物特有的;它们最近也发生在兔形目动物（兔，Oryctolagus cuniculus）和反刍动物（牛，Bos taurus）谱系中，尽管不是在其他哺乳动物类群中。我们的结论是，Abp基因经历了反复爆发的基因复制和适应性序列多样化驱动这些基因的参与化学感觉和/或性别鉴定。
The draft mouse (Mus musculus) genome sequence revealed an unexpected proliferation of gene duplicates encoding a family of secretoglobin proteins including the androgen-binding protein (ABP) α, β and γ subunits. Further investigation of 14 α-like (Abpa) and 13 β- or γ-like (Abpbg) undisrupted gene sequences revealed a rich diversity of developmental stage-, sex- and tissue-specific expression. Despite these studies, our understanding of the evolution of this gene family remains incomplete. Questions arise from imperfections in the initial mouse genome assembly and a dearth of information about the gene family structure in other rodents and mammals. Here, we interrogate the latest 'finished' mouse (Mus musculus) genome sequence assembly to show that the Abp gene repertoire is, in fact, twice as large as reported previously, with 30 Abpa and 34 Abpbg genes and pseudogenes. All of these have arisen since the last common ancestor with rat (Rattus norvegicus). We then demonstrate, by sequencing homologs from species within the Mus genus, that this burst of gene duplication occurred very recently, within the past seven million years. Finally, we survey Abp orthologs in genomes from across the mammalian clade and show that bursts of Abp gene duplications are not specific to the murid rodents; they also occurred recently in the lagomorph (rabbit, Oryctolagus cuniculus) and ruminant (cattle, Bos taurus) lineages, although not in other mammalian taxa. We conclude that Abp genes have undergone repeated bursts of gene duplication and adaptive sequence diversification driven by these genes' participation in chemosensation and/or sexual identification.
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DOI：
10.1111/j.1095-8312.1987.tb00288.x
发表时间：
1987-01-01
影响因子：
1.9
作者：
BONHOMME, F;GUENET, JL;BULFIELD, G
通讯作者：
BULFIELD, G
影响因子：
13.8
作者：
Jeanmougin, F;Thompson, JD;Gibson, TJ
通讯作者：
Gibson, TJ
影响因子：
2.4
作者：
KARN, RC
通讯作者：
KARN, RC
DOI：
10.1073/pnas.0501589102
发表时间：
2005-04-19
影响因子：
11.1
作者：
Grus, WE;Shi, P;Zhang, JZ
通讯作者：
Zhang, JZ
影响因子：
10.7
作者：
Adkins, RM;Gelke, EL;Honeycutt, RL
通讯作者：
Honeycutt, RL