STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.
STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.
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DOI：
10.1016/j.chom.2014.06.004
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发表时间：
2014-07-09
影响因子：
30.3
通讯作者：
Preiser PR
中科院分区：
文献类型：
--
作者：
Niang M;Bei AK;Madnani KG;Pelly S;Dankwa S;Kanjee U;Gunalan K;Amaladoss A;Yeo KP;Bob NS;Malleret B;Duraisingh MT;Preiser PR
Variant surface antigens play an important role in the pathogenesis of Plasmodium falciparum malaria. To date, intensive work has mainly focused on the role in parasite virulence of the P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) encoded by the var multigene family. Two other multigene families coding for STEVOR and RIFIN have recently also been shown to be expressed in the invasive merozoite as well as on the surface of the infected erythrocyte, implicating them as potential parasite virulence factors. Here we report that STEVOR is an erythrocyte-binding protein recognizing Glycophorin C on the red blood cell (RBC) surface. STEVOR expression on the RBC leads to PfEMP1-independent rosette formation, while antibodies targeting STEVOR in the merozoite can effectively inhibit invasion. Our results suggest a novel role of STEVOR in enabling infected erythrocytes at the schizont stage to bind uninfected erythrocytes to form rosettes, thereby protecting released merozoites from immune detection.
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DOI：
10.1086/510756
发表时间：
2007-02-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Anstey NM;Handojo T;Pain MC;Kenangalem E;Tjitra E;Price RN;Maguire GP
通讯作者：
Maguire GP
影响因子：
3
作者：
Claessens A;Ghumra A;Gupta AP;Mok S;Bozdech Z;Rowe JA
通讯作者：
Rowe JA
影响因子：
12.8
作者：
Bei, Amy K.;DeSimone, Tiffany M.;Badiane, Aida S.;Ahouidi, Ambroise D.;Dieye, Tandakha;Ndiaye, Daouda;Sarr, Ousmane;Ndir, Omar;Mboup, Souleymane;Duraisingh, Manoj T.
通讯作者：
Duraisingh, Manoj T.
影响因子：
64.8
作者：
Carlton, Jane M.;Adams, John H.;Silva, Joana C.;Bidwell, Shelby L.;Lorenzi, Hernan;Caler, Elisabet;Crabtree, Jonathan;Angiuoli, Samuel V.;Merino, Emilio F.;Amedeo, Paolo;Cheng, Qin;Coulson, Richard M. R.;Crabb, Brendan S.;del Portillo, Hernando A.;Essien, Kobby;Feldblyum, Tamara V.;Fernandez-Becerra, Carmen;Gilson, Paul R.;Gueye, Amy H.;Guo, Xiang;Kang'a, Simon;Kooij, Taco W. A.;Korsinczky, Michael;Meyer, Esmeralda V. -S.;Nene, Vish;Paulsen, Ian;White, Owen;Ralph, Stuart A.;Ren, Qinghu;Sargeant, Tobias J.;Salzberg, Steven L.;Stoeckert, Christian J.;Sullivan, Steven A.;Yamamoto, Marcio M.;Hoffman, Stephen L.;Wortman, Jennifer R.;Gardner, Malcolm J.;Galinski, Mary R.;Barnwell, John W.;Fraser-Liggett, Claire M.
通讯作者：
Fraser-Liggett, Claire M.
DOI：
10.4269/ajtmh.2009.09-0406
发表时间：
2009-12
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Doumbo OK;Thera MA;Koné AK;Raza A;Tempest LJ;Lyke KE;Plowe CV;Rowe JA
通讯作者：
Rowe JA