Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity.
Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity.
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DOI：
10.3389/fimmu.2018.00169
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发表时间：
2018
影响因子：
7.3
通讯作者：
Thompson D
中科院分区：
文献类型：
--
作者：
Trim W;Turner JE;Thompson D
与肥胖一样，衰老通常与代谢和炎症过程的改变有关，导致以代谢控制不良、胰岛素不敏感和炎症为特征的疾病的发病率。老龄化群体还表现出称为免疫衰老的免疫能力下降，这有助于或可能由称为“炎症”的慢性低度炎症驱动。近年来，动物和人类研究已经开始揭示脂肪组织基质部分中的免疫细胞在驱动肥胖症带来的健康并发症中的作用，但在衰老中的免疫代谢脂肪功能方面进行的工作相对较少。现在很清楚，肥胖症脂肪组织内异常的免疫功能-包括促炎免疫细胞群的积累-在系统性慢性、低度炎症的发展中起主要作用，并限制脂肪细胞的功能，导致脂肪处理能力受损。因此，这些变化增加了多器官功能障碍和疾病发作的机会。考虑到免疫系统在肥胖相关的代谢和炎症疾病中的重要作用，进一步了解免疫过程和脂肪组织功能之间的相互作用至关重要，确定这种相互作用是否有助于年龄相关的免疫代谢功能障碍和炎症。因此，本文的目的是总结脂肪组织和免疫系统之间的相互作用如何随着衰老而变化，可能导致与年龄相关的炎症活动增加和代谢控制丧失。为了了解所涉及的潜在机制，将与目前从肥胖调查中获得的知识进行比较。我们还强调了研究中的差距，并根据目前的证据提出了潜在的未来方向。
Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation. Ageing populations also exhibit a decline in immune competence referred to as immunosenescence, which contributes to, or might be driven by chronic, low-grade inflammation termed “inflammageing”. In recent years, animal and human studies have started to uncover a role for immune cells within the stromal fraction of adipose tissue in driving the health complications that come with obesity, but relatively little work has been conducted in the context of immunometabolic adipose function in ageing. It is now clear that aberrant immune function within adipose tissue in obesity—including an accumulation of pro-inflammatory immune cell populations—plays a major role in the development of systemic chronic, low-grade inflammation, and limiting the function of adipocytes leading to an impaired fat handling capacity. As a consequence, these changes increase the chance of multiorgan dysfunction and disease onset. Considering the important role of the immune system in obesity-associated metabolic and inflammatory diseases, it is critically important to further understand the interplay between immunological processes and adipose tissue function, establishing whether this interaction contributes to age-associated immunometabolic dysfunction and inflammation. Therefore, the aim of this article is to summarise how the interaction between adipose tissue and the immune system changes with ageing, likely contributing to the age-associated increase in inflammatory activity and loss of metabolic control. To understand the potential mechanisms involved, parallels will be drawn to the current knowledge derived from investigations in obesity. We also highlight gaps in research and propose potential future directions based on the current evidence.
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影响因子：
3.7
作者：
Caesar R;Manieri M;Kelder T;Boekschoten M;Evelo C;Müller M;Kooistra T;Cinti S;Kleemann R;Drevon CA
通讯作者：
Drevon CA
影响因子：
5.9
作者：
Bonamichi BDSF;Lee J
通讯作者：
Lee J
巨噬细胞的局部扩散有助于与肥胖相关的脂肪组织炎症。
影响因子：
29
作者：
Amano SU;Cohen JL;Vangala P;Tencerova M;Nicoloro SM;Yawe JC;Shen Y;Czech MP;Aouadi M
通讯作者：
Aouadi M
影响因子：
3.9
作者：
Borrego, F;Alonso, MC;Solana, R
通讯作者：
Solana, R
DOI：
10.1093/gerona/63.5.447
发表时间：
2008-05-01
影响因子：
5.1
作者：
Atzmon, Gil;Pollin, Toni I.;Barzilai, Nir
通讯作者：
Barzilai, Nir