Long Noncoding RNA LINC00941 Promotes Cell Proliferation and Invasion by Interacting with hnRNPK in Oral Squamous Cell Carcinoma
Long Noncoding RNA LINC00941 Promotes Cell Proliferation and Invasion by Interacting with hnRNPK in Oral Squamous Cell Carcinoma
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长非编码RNA LINC00941通过与口腔鳞状细胞癌中的hnRNPK相互作用促进细胞增殖和侵袭
DOI：
10.1080/01635581.2022.2027473
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Junyu Wang
中科院分区：
文献类型：
--
作者：
Jie Liu;Zhenxing Li;Ting Zhang;Chunhui Wang;Wen Chen;Danfeng Zhang;Junyu Wang
抽象的口服鳞状细胞癌（OSCC）是头部，颈部和口腔的普遍癌。最近在CON中报道了涉及长的非编码RNA（LNCRNA）在改变基因表达中起关键调节作用的作用的研究。
Abstract Oral squamous cell carcinoma (OSCC) is a prevalent carcinoma of the head, neck and mouth. Recently studies involving the role of long noncoding RNAs (lncRNAs) that play key regulatory roles in altering gene expression has been reported in the context of promoting tumorigenesis. However, the functions of lncRNAs in the context of oral squamous cell carcinoma have not been extensively described. In this study, we report a never identified before lncRNA, LINC00941, which was highly expressed in OSCC tissues and cells. Expression of LINC00941 promoted cell proliferation, migration, invasion, and metastasis of OSCC cells In Vitro by inducing epithelial-mesenchymal transition (EMT) and activating the Wnt/β-catenin signaling cascade. In silico analyses revealed heterogeneous nuclear ribonucleoprotein K (hnRNPK) to be a strong positive regulator of LINC00941 activity. Experimental verification of this association revealed a direct interaction of LINC00941 and hnRNPK to induce cell growth and invasion by activating EMT in OSCC cells. Therefore, our study reports that LINC00941 promotes progression of OSCC by its interaction with hnRNPK, and it may present a promising strategy for diagnosis and treatment of OSCC.
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影响因子：
37.3
作者：
Gibb EA;Brown CJ;Lam WL
通讯作者：
Lam WL
影响因子：
64.5
作者：
Huarte M;Guttman M;Feldser D;Garber M;Koziol MJ;Kenzelmann-Broz D;Khalil AM;Zuk O;Amit I;Rabani M;Attardi LD;Regev A;Lander ES;Jacks T;Rinn JL
通讯作者：
Rinn JL
DOI：
10.1111/jop.12167
发表时间：
2014-08
期刊：
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
影响因子：
--
作者：
M. Yanase;K. Kato;K. Yoshizawa;Natsuyo Noguchi;H. Kitahara;Hiroyuki Nakamura
通讯作者：
M. Yanase;K. Kato;K. Yoshizawa;Natsuyo Noguchi;H. Kitahara;Hiroyuki Nakamura
波形蛋白高表达与淋巴结转移相关，预示口腔鳞状细胞癌预后不良。
影响因子：
4.6
作者：
Liu S;Liu L;Ye W;Ye D;Wang T;Guo W;Liao Y;Xu D;Song H;Zhang L;Zhu H;Deng J;Zhang Z
通讯作者：
Zhang Z
影响因子：
14.9
作者：
Moran VA;Perera RJ;Khalil AM
通讯作者：
Khalil AM