Altered Brain Developmental Trajectories in Adolescents After Initiating Drinking.
Altered Brain Developmental Trajectories in Adolescents After Initiating Drinking.
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饮酒后，青少年的大脑发育轨迹改变了。
DOI：
10.1176/appi.ajp.2017.17040469
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发表时间：
2018-04-01
期刊：
影响因子：
--
通讯作者：
Sullivan EV
中科院分区：
文献类型：
--
作者：
Pfefferbaum A;Kwon D;Brumback T;Thompson WK;Cummins K;Tapert SF;Brown SA;Colrain IM;Baker FC;Prouty D;De Bellis MD;Clark DB;Nagel BJ;Chu W;Park SH;Pohl KM;Sullivan EV
We sought evidence for altered adolescent brain growth trajectory associated with moderate and heavy alcohol use in a national, multi-site, prospective study of hundreds of participants studied before and after they initiated harmful levels of alcohol use. This study examined 483 adolescents (12-21 years) before initiation of drinking and one and two years later. At the two-year session, 356 participants continued to meet study entry no/low alcohol consumption criteria, 65 initiated moderate drinking, and 62 initiated heavy drinking. MRI quantified regional cortical and white matter volumes. Percent change/year (slopes) of adolescents who continued to meet no/low criteria served as developmental control trajectories against which to compare youth who initiated moderate or heavy drinking. In no/low drinkers, gray matter volume declined throughout adolescence and slowed in many regions in later adolescence. Complementing gray matter declines, white matter regions grew at faster rates at younger ages and slowed toward young adulthood. Youth who initiated heavy drinking exhibited frontal cortical gray matter trajectory acceleration divergent from the norm. Although significant effects on trajectories were not forthcoming in moderate drinkers, their intermediate position between no/low and heavy drinkers suggested a dose effect. Neither marijuana co-use nor baseline volumes contributed significantly to the alcohol effect. Initiation of drinking during adolescence—with or without marijuana co-use—disordered normal brain growth trajectories. Factors possibly contributing to abnormal cortical volume trajectories include peak consumption in the past year and family history of alcohol misuse.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
3.3
作者：
Brumback TY;Worley M;Nguyen-Louie TT;Squeglia LM;Jacobus J;Tapert SF
通讯作者：
Tapert SF
影响因子：
5.7
作者：
Ducharme S;Albaugh MD;Nguyen TV;Hudziak JJ;Mateos-Pérez JM;Labbe A;Evans AC;Karama S;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
影响因子：
3.4
作者：
Schuckit, Marc A.;Smith, Tom L.;Hesselbrock, Victor
通讯作者：
Hesselbrock, Victor