Are the Anterior and Mid-Cingulate Cortices Distinct in Rodents?
Are the Anterior and Mid-Cingulate Cortices Distinct in Rodents?
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DOI：
10.3389/fnana.2022.914359
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发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
前额叶皮层（PFC）参与认知控制，情绪调节和动机。在这篇透视文章中，我们讨论了内侧前额叶皮层（mPFC）的分区的命名，因为PFC分区的解剖学定义一直令人困惑。虽然中扣带皮层（MCC）和前扣带皮层（ACC）在人类和非人类灵长类动物中具有不同的特征，但目前还不清楚这些区域在啮齿动物中是否具有不同的功能。啮齿类动物扣带皮层的精确定位对于物种间的比较是很重要的。根据我们的数据，提出了将啮齿动物扣带皮层命名为前扣带皮层（aCg）和中扣带皮层（mCg）的建议。我们发现证据表明，不同的皮质-皮质预测从aCg和mCg的PrL。aCg→PrL神经元主要分布在第VI层，而mCg→PrL神经元主要分布在第V层。此外，aCg向PrL投射的神经元存在性别差异，男性的第V层神经元比例高于女性。基于这种层状分布，并考虑到层V和VI发送传出投射到不同的大脑区域，如脑干，杏仁核，丘脑，我们建议，aCg和mCg需要被认为是单独的实体为未来的啮齿动物研究。这一新的定义将使啮齿动物扣带皮层在认知的各个方面的作用更加明确，并有助于扣带皮层研究中的种间比较。
The prefrontal cortex (PFC) is involved in cognitive control, emotional regulation, and motivation. In this Perspective article, we discuss the nomenclature of the subdivisions of the medial prefrontal cortex (mPFC), since the anatomical definitions of the PFC subregions have been confusing. Although the mid-cingulate cortex (MCC) and anterior cingulate cortex (ACC) have distinct features in humans and non-human primates, it is unclear whether these regions serve different functions in rodents. Accurate mapping of the cingulate cortex in rodents is important to allow comparisons between species. A proposed change in the nomenclature of the rodent cingulate cortex to anterior cingulate cortex (aCg) and mid-cingulate cortex (mCg) is presented based on our data. We show evidence for distinct cortico-cortical projections from the aCg and mCg to the PrL. The aCg→PrL neurons were abundant in layer VI, while the mCg→PrL neurons were mainly distributed in layer V. In addition, a sex difference was detected in the aCg, with males having a higher proportion of layer V neurons projecting to the PrL than females. Based on this laminar distribution and considering that layer V and VI send efferent projections to different brain areas such as the brain stem, amygdala, and thalamus, we propose that aCg and mCg need to be considered separate entities for future rodent studies. This new definition will put into perspective the role of rodent cingulate cortex in diverse aspects of cognition and facilitate interspecies comparisons in cingulate cortex research.
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影响因子：
34.7
作者：
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