Weight loss regimen in obese and overweight individuals is associated with reduced cartilage degeneration: 96-month data from the Osteoarthritis Initiative.
Weight loss regimen in obese and overweight individuals is associated with reduced cartilage degeneration: 96-month data from the Osteoarthritis Initiative.
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DOI：
10.1016/j.joca.2019.01.018
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发表时间：
2019-06
影响因子：
7
通讯作者：
Link, T. M.
中科院分区：
文献类型：
--
作者：
Gersing, A. S.;Schwaiger, B. J.;Nevitt, M. C.;Zarnowski, J.;Joseph, G. B.;Feuerriegel, G.;Jungmann, P. M.;Guimaraes, J. B.;Facchetti, L.;McCulloch, C. E.;Link, T. M.
旨在调查体重恒定的超重和肥胖参与者与体重减轻的参与者在 96 个月内膝关节软骨成分的变化，并评估不同的减肥方案与这些变化之间的关系。我们研究了来自骨关节炎倡议的 760 名参与者（年龄 62.6±9.0 岁；465 名女性）的右膝，这些参与者的基线 BMI > 25kg/m2，患有轻度至中度或具有膝骨关节炎的危险因素。将体重减轻的参与者（72 个月内> 基线 BMI 的 5%；N=380）与体重稳定的对照组（SW，N=380）进行比较。根据减肥方法（饮食和运动、仅饮食、仅运动）对减肥参与者进行分类，并与体重稳定的参与者进行比较。在基线、48 个月和 96 个月时进行 3T MRI。使用混合随机效应模型分析了通过 T2 映射测量的体重减轻和体重减轻方法与软骨成分变化之间的关联。与SW相比，体重减轻与整体（所有区室平均）软骨T2（组间T2毫秒/年变化的平均差异[95%CI]调整后的平均差异：0.24[0.20，0.41]毫秒/年；P<0.001）和整体深层软骨T2（0.35[0.20，0.42]毫秒/年；P<0.001）的增长显着缓慢相关； P<0.001），表明与 SW 组相比，节食组和节食加运动组的整体 T2 增加较慢，但仅运动组则不然（分别为 P=0.042、P=0.003 和 P=0.85）。我们的结果表明，减肥可能会在 96 个月内减缓膝关节软骨退化，并且这些潜在益处可能因减肥方法而异。
To investigate change in knee cartilage composition over 96 months in overweight and obese participants with constant weight compared to those with weight loss, and to assess how different weight loss regimens are associated with these changes. We studied right knees of 760 participants (age 62.6±9.0y; 465 females) with a baseline BMI>25kg/m2 from the Osteoarthritis Initiative with mild to moderate or with risk factors for knee osteoarthritis. Participants losing weight (>5% of baseline BMI over 72 months; N=380) were compared to controls with stable weight (SW, N=380). Participants losing weight were categorized based on weight loss method (diet and exercise, diet only, exercise only) and compared to those with stable weight. MRI at 3T was performed at baseline, 48- and 96-months. The association of weight loss and weight loss method with change in cartilage composition, measured with T2 mapping, was analyzed using mixed random effects models. Compared to SW, weight loss was associated with a significantly slower increase in global (averaged over all compartments) cartilage T2 ((adjusted mean difference of change in T2 ms/year [95%CI] between the groups: 0.24 [0.20, 0.41] ms/year; P<0.001) and global deep layer cartilage T2 (0.35 [0.20, 0.42] ms/year; P<0.001), suggesting slower cartilage deterioration. Compared to the SW group, slower increases in global T2 were observed in the diet and diet and exercise groups, but not in the exercise only group (P=0.042, P=0.003 and P=0.85, respectively). Our results suggest that weight loss may slow knee cartilage degeneration over 96 months, and that these potential benefits may differ by method of weight loss.
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影响因子：
4.7
作者：
Baum, Thomas;Joseph, Gabby B.;Arulanandan, Ahilan;Nardo, Lorenzo;Virayavanich, Warapat;Carballido-Gamio, Julio;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
通讯作者：
Link, Thomas M.
影响因子：
3.3
作者：
Carballido-Gamio, Julio;Joseph, Gabby B.;Majumdar, Sharmila
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Majumdar, Sharmila
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Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
19.7
作者：
Mosher, TJ;Dardzinski, BJ;Smith, MB
通讯作者：
Smith, MB
影响因子：
7
作者：
Peterfy CG;Schneider E;Nevitt M
通讯作者：
Nevitt M