Habituation, sensitization, and emotional valence modulation of pain responses
Habituation, sensitization, and emotional valence modulation of pain responses
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疼痛反应的习惯、敏化和情绪效价调节
DOI：
10.1016/j.pain.2009.11.018
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发表时间：
2010
期刊：
影响因子：
7.4
通讯作者：
Amy E. Williams
中科院分区：
文献类型：
--
作者：
J. Rhudy;E. Bartley;Amy E. Williams
伤害感受的情绪控制（ECON）范式涉及在传递痛苦刺激期间呈现充满情绪的图片。在几项ECON研究中，不愉快的图片增强了疼痛和伤害感受，而愉快的图片抑制了疼痛和伤害感受。然而，目前尚不清楚情绪效价（不愉快，中性，愉快）是否会影响测试期间发生的疼痛反应的习惯化或敏感化。事实上，ECON假设疼痛的情绪效价调节在整个测试过程中是一致的;否则，对效价调节（不愉快>中性>愉快）的解释可能会受到威胁。为了解决这个问题，本研究（N= 120）提出了108张图片，不同的情绪效价。在图片期间和图片之间，提供了52个阈上皮肤电刺激以引起疼痛、伤害性屈曲反射（NFR）和疼痛诱发的皮肤电导反应（SCR）。混合效应方差分析证实，受试者内疼痛反应的变化受到刺激重复（NFR和SCR习惯化，疼痛评级敏感）和情绪效价（反应最高，在不愉快的图片，中间在中性图片，和最低在愉快的图片）。然而，习惯化/敏感化斜率不受情绪效价的影响，因此表明在整个测试过程中始终观察到情绪效价调节。这些结果为ECON范式提供了额外的验证，并表明负责疼痛和伤害感受的情绪调节的电路比负责阈上冲击反应的电路更不易于习惯化或敏化。
The Emotional Controls of Nociception (ECON) paradigm involves the presentation of emotionally-charged pictures during which painful stimuli are delivered. Across several ECON studies, unpleasant pictures enhanced pain and nociception, whereas pleasant pictures inhibited pain and nociception. However, at this time it is unknown whether emotional valence (unpleasant, neutral, pleasant) influences the habituation or sensitization of pain responses that occurs within a testing session. Indeed, ECON assumes that emotional valence modulation of pain is consistent throughout testing; otherwise the interpretation of valence modulation (unpleasant> neutral> pleasant) could be threatened. To address this issue, the present study (N= 120) presented 108 pictures that varied in emotional valence. During and in between pictures, 52 suprathreshold electrocutaneous stimuli were delivered to evoke pain, the nociceptive flexion reflex [NFR], and pain-evoked skin conductance response [SCR]. Mixed effects ANOVAs verified that within-subject changes in pain responses were influenced by stimulus repetition (NFR and SCR habituated, pain ratings sensitized) and emotional valence (responses were highest during unpleasant pictures, intermediate during neutral pictures, and lowest during pleasant pictures). However, habituation/sensitization slopes were unaffected by emotional valence, thus indicating emotional valence modulation was consistently observed throughout the testing session. These results provide additional validation for the ECON paradigm and suggest that the circuit responsible for emotional modulation of pain and nociception is less susceptible to habituation or sensitization than the circuits responsible for responses to suprathreshold shocks.
影响因子：
3.7
作者：
Edwards, L;McIntyre, D;Martin, U
通讯作者：
Martin, U
影响因子：
1.9
作者：
BRADLEY, MM;LANG, PJ;CUTHBERT, BN
通讯作者：
CUTHBERT, BN
DOI：
10.1016/0005-7916(94)90063-9
发表时间：
1994-03-01
影响因子：
1.8
作者：
BRADLEY, MM;LANG, PJ
通讯作者：
LANG, PJ