Epithelial-Mesenchymal Transition Expression Profile Stratifies Human Glioma into Two Distinct Tumor-Immune Subtypes.
Epithelial-Mesenchymal Transition Expression Profile Stratifies Human Glioma into Two Distinct Tumor-Immune Subtypes.
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DOI：
10.3390/brainsci13030447
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发表时间：
2023-03-05
期刊：
影响因子：
3.3
通讯作者：
Fu, Xiaojun
中科院分区：
文献类型：
--
作者：
Ren, Changyuan;Chang, Xin;Li, Shouwei;Yan, Changxiang;Fu, Xiaojun
胶质瘤是人类中枢神经系统中发病率最高、预后最差的原发性肿瘤。上皮间质转化（EMT）和免疫反应是导致其预后最差的两个关键过程。然而，这两个过程之间的全面关联仍然难以捉摸。从公共数据库中下载胶质瘤患者的mRNA表达谱和相应的临床数据。收集EMT相关基因并提供在dbEMT数据库中。进行风险评分、Lasso回归和富集分析以进行功能验证。在我们的研究中，我们使用EMT基因表达谱的无监督聚类将胶质瘤分为两种亚型。我们通过在三个独立的队列中进行测试来评估该分类系统的可靠性。每种亚型具有不同的临床和免疫系统特征。这项研究表明，神经胶质瘤中EMT和免疫反应之间可能存在联系。
Glioma is the primary tumor with the highest incidence and the worst prognosis in the human central nervous system. Epithelial–mesenchymal transition (EMT) and immune responses are two crucial processes that contribute to it having the worst prognosis. However, a comprehensive correlation between these two processes remains elusive. The mRNA expression profiles and corresponding clinical data of patients with glioma were downloaded from public databases. EMT-related genes were collected and provided in the dbEMT database. Risk scores, Lasso regression, and enrichment analysis were conducted for functional validation. In our study, we used unsupervised clustering of EMT gene expression profiles to classify gliomas into two subtypes. We assessed the reliability of this classification system by testing it in three independent cohorts. Each subtype had different clinical and immune system characteristics. The study suggests a possible link between EMT and immune responses in gliomas.
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影响因子：
13.3
作者：
Iser, Isabele C.;Pereira, Mariana B.;Wink, Marcia R.
通讯作者：
Wink, Marcia R.
影响因子：
15.9
作者：
Ostrom, Quinn T.;Bauchet, Luc;Barnholtz-Sloan, Jill S.
通讯作者：
Barnholtz-Sloan, Jill S.
肿瘤微环境中癌症相关成纤维细胞和免疫细胞之间的串扰：新发现和未来前景。
影响因子：
37.3
作者：
Mao X;Xu J;Wang W;Liang C;Hua J;Liu J;Zhang B;Meng Q;Yu X;Shi S
通讯作者：
Shi S
影响因子：
4.6
作者：
Li J;Huang W;Chen J;Li Z;Liu B;Wang P;Zhang J
通讯作者：
Zhang J
DOI：
10.15252/embj.2021108647
发表时间：
2021-09-15
期刊：
The EMBO journal
影响因子：
--
作者：
Brabletz S;Schuhwerk H;Brabletz T;Stemmler MP
通讯作者：
Stemmler MP