Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells.
Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells.
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DOI：
10.3389/fphar.2022.978421
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
过敏性哮喘患者的数量逐年上升，激素类药物如地塞米松有其独特的优势，也有一定的局限性。在过敏性疾病尤其是过敏性哮喘的治疗中，提高免疫抑制细胞如Treg细胞的百分比或功能，可能会取得良好的效果。在良好的临床疗效基础上，我们发现，在控制过敏性哮喘的症状和抑制过敏性哮喘的炎症反应方面，国敏康（GMK）特别是高浓度的GMK可以达到与地塞米松相似的效果。在我们的研究中，GMK可以抑制炎症细胞的募集，减少粘液的产生，降低气道阻力。此外，GMK还能重建Th 1/2和Treg/Th 17细胞的细胞免疫平衡。代谢物组学结果显示DL-谷氨酰胺、L-焦谷氨酸、前列腺素b1、前列腺素e2和3，4-二羟基氢化肉桂酸是代谢生物标志物，并且与Th 1/2和Treg/Th 17细胞平衡相关。GMK还可以改变过敏性哮喘小鼠模型中的肠道微生物群。Muriculum属、Clostridium属GCA 900066575、Klebsiella属、Desulfovibrio属、Rikenellaceae属RC 9肠道群、Chitinophagaceae科、Nocardioidaceae科和Corynebacterium属是GMK处理的肠道微生物群生物标志物。在这些生物标志物中，Muriculum属是与Th 1/2和Treg/Th 17细胞平衡相关的肠道微生物群生物标志物。有趣的是，我们首次发现DL-谷氨酰胺，L-焦谷氨酸，前列腺素b1，前列腺素e2和3，4-二羟基氢化肉桂酸都与Muriculum属有关。GMK将成为治疗嗜酸性粒细胞性哮喘的新策略，生物标志物也将成为新的研究方向。
The number of patients with allergic asthma is rising yearly, and hormonal drugs, such as dexamethasone, have unique advantages and certain limitations. In the treatment of allergic diseases especially allergic asthma, increasing the percentage or the function of immunosuppressive cells, such as Treg cells, may achieve a good effect. On the basis of good clinical results, we found that Guominkang (GMK) especially high-concentration GMK can achieve a similar effect with dexamethasone in controlling the symptoms of allergic asthma and inhibiting inflammation of allergic asthma. In our study, GMK can inhibit the recruitment of inflammatory cells, decrease mucus production, and reduce airway resistance. Besides, GMK can reconstruct the cellular immune balance of Th1/2 and Treg/Th17 cells. Metabolome results show that DL-glutamine, L-pyroglutamic acid, prostaglandin b1, prostaglandin e2, and 3,4-dihydroxyhydrocinnamic acid are the metabolic biomarkers and are associated with Th1/2 and Treg/Th17 cell balance. GMK can also change the gut microbiota in the allergic asthma mouse model. The genus_Muriculum, genus_(Clostridium) GCA900066575, genus_klebsiella, genus_Desulfovibrio, genus_Rikenellaceae RC9 gut group, family_Chitinophagaceae, family_Nocardioidaceae, and genus_Corynebacterium are gut microbiota biomarkers treated by GMK. Among these biomarkers, genus_Muriculum is the gut microbiota biomarker associated with Th1/2 and Treg/Th17 cell balance. Interestingly, we first found that DL-glutamine, L-pyroglutamic acid, prostaglandin b1, prostaglandin e2, and 3,4-dihydroxyhydrocinnamic acid are all associated with genus_Muriculum. GMK will be a new strategy for the treatment of eosinophilic asthma, and biomarkers will also be a new research direction.
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DOI：
10.4049/jimmunol.0902185
发表时间：
2010-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Finkelman FD;Hogan SP;Hershey GK;Rothenberg ME;Wills-Karp M
通讯作者：
Wills-Karp M
影响因子：
9.6
作者：
Hanania, Nicola A.
通讯作者：
Hanania, Nicola A.
小檗碱通过调节结肠肠道微生物群调节 Treg/Th17 平衡来治疗溃疡性结肠炎
影响因子：
5.6
作者：
Cui H;Cai Y;Wang L;Jia B;Li J;Zhao S;Chu X;Lin J;Zhang X;Bian Y;Zhuang P
通讯作者：
Zhuang P
影响因子：
64.8
作者：
Gavin, Marc A.;Rasmussen, Jeffrey P.;Rudensky, Alexander Y.
通讯作者：
Rudensky, Alexander Y.
影响因子：
56.9
作者：
Hori, S;Nomura, T;Sakaguchi, S
通讯作者：
Sakaguchi, S