Wild bird migration across the Qinghai-Tibetan plateau: a transmission route for highly pathogenic H5N1.
Wild bird migration across the Qinghai-Tibetan plateau: a transmission route for highly pathogenic H5N1.
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野鸟穿越青藏高原的迁徙：高致病性H5N1的传播途径
DOI：
10.1371/journal.pone.0017622
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发表时间：
2011-03-09
期刊：
影响因子：
3.7
通讯作者：
Newman SH
中科院分区：
文献类型：
--
作者：
Prosser DJ;Cui P;Takekawa JY;Tang M;Hou Y;Collins BM;Yan B;Hill NJ;Li T;Li Y;Lei F;Guo S;Xing Z;He Y;Zhou Y;Douglas DC;Perry WM;Newman SH
关于野生鸟类是否在高致病性H5N1禽流感病毒的传播中发挥了作用，中国中部的青海湖一直处于争论的中心。2005年，青海湖发生了一场前所未有的动物流行病，导致6000多只候鸟死亡，其中包括3000多只斑头雁。H5N1随后传播到欧洲和非洲，并在随后几年中多次在中亚飞行路线上的野生鸟类中重新出现。为了更好地了解野生鸟类在H5N1传播中的潜在作用，我们研究了青海湖用GPS卫星发射机标记的斑头雁的运动与病毒爆发和疾病危险因素的关系。鹅的活动与三个潜在的H5N1病毒来源（家禽养殖场、圈养斑头鹅设施和H5N1暴发地点）之间的时空一致性表明，越冬地存在大量病毒溢出和候鸟感染的机会。一些鹅的快速迁徙以及从西藏和青海湖鹅中分离的H5N1病毒的遗传相关性支持了它们作为H5N1病毒载体的潜力。结论/意义本研究首次将H5N1病毒的系统发育与其宿主的空间生态进行了比较，综合结果提示野生鸟类在该地区的传播中发挥了作用。
BackgroundQinghai Lake in central China has been at the center of debate on whether wild birds play a role in circulation of highly pathogenic avian influenza virus H5N1. In 2005, an unprecedented epizootic at Qinghai Lake killed more than 6000 migratory birds including over 3000 bar-headed geese(Anser indicus). H5N1 subsequently spread to Europe and Africa, and in following years has re-emerged in wild birds along the Central Asia flyway several times.Methodology/Principal FindingsTo better understand the potential involvement of wild birds in the spread of H5N1, we studied the movements of bar-headed geese marked with GPS satellite transmitters at Qinghai Lake in relation to virus outbreaks and disease risk factors. We discovered a previously undocumented migratory pathway between Qinghai Lake and the Lhasa Valley of Tibet where 93% of the 29 marked geese overwintered. From 2003–2009, sixteen outbreaks in poultry or wild birds were confirmed on the Qinghai-Tibet Plateau, and the majority were located within the migratory pathway of the geese. Spatial and temporal concordance between goose movements and three potential H5N1 virus sources (poultry farms, a captive bar-headed goose facility, and H5N1 outbreak locations) indicated ample opportunities existed for virus spillover and infection of migratory geese on the wintering grounds. Their potential as a vector of H5N1 was supported by rapid migration movements of some geese and genetic relatedness of H5N1 virus isolated from geese in Tibet and Qinghai Lake.Conclusions/SignificanceThis is the first study to compare phylogenetics of the virus with spatial ecology of its host, and the combined results suggest that wild birds play a role in the spread of H5N1 in this region. However, the strength of the evidence would be improved with additional sequences from both poultry and wild birds on the Qinghai-Tibet Plateau where H5N1 has a clear stronghold.
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DOI：
10.1073/pnas.0511120103
发表时间：
2006-02-21
影响因子：
11.1
作者：
Chen, H;Smith, GJD;Guan, Y
通讯作者：
Guan, Y
影响因子：
5.4
作者：
Chen, HL;Li, YB;Kawaoka, Y
通讯作者：
Kawaoka, Y
影响因子：
9.4
作者：
Fouchier, RAM;Bestebroer, TM;Osterhaus, ADME
通讯作者：
Osterhaus, ADME
影响因子：
3.3
作者：
Alexander, DJ
通讯作者：
Alexander, DJ
影响因子：
2.3
作者：
Blejwas, Karen M.;Williams, Christen L.;Jaeger, Michael M.
通讯作者：
Jaeger, Michael M.