From maternal breath to infant's cells: Impact of maternal respiratory infections on infants 'immune responses.
From maternal breath to infant's cells: Impact of maternal respiratory infections on infants 'immune responses.
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DOI：
10.3389/fped.2022.1046100
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发表时间：
2022
影响因子：
2.6
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中科院分区：
文献类型：
--
作者：
慢性感染后母体来源抗原的宫内暴露与婴儿免疫应答的调节、对产后感染的不同易感性和对疫苗的免疫应答相关。母体环境，包括内部（微生物群）和外部（暴露于环境微生物），也调节婴儿的免疫反应，但也调节出生后的临床表型。流感和COVID-19等普遍存在的呼吸道病原体的垂直传播并不常见。有证据表明，在子宫内暴露于母体流感和SARS-CoV-2感染可能对发育中的免疫系统产生重大影响，激活先天性和适应性反应，可能与胎盘炎症有关。在这里，我们回顾了与气道，全身性和胎盘炎症相关的母体呼吸道感染以及母体微生物群的变化如何影响婴儿出生后的免疫反应。在母体呼吸道感染后观察到的免疫修饰的临床影响尚未探索。鉴于怀孕期间呼吸道感染（COVID-19、流感以及RSV和HMPV）的频率很高，对全球儿童健康的影响可能很重要。
In utero exposure to maternally-derived antigens following chronic infection is associated with modulation of infants ‘immune response, differential susceptibility to post-natal infections and immune response toward vaccines. The maternal environment, both internal (microbiota) and external (exposure to environmental microbes) also modulates infant's immune response but also the clinical phenotype after birth. Vertical transmission of ubiquitous respiratory pathogens such as influenza and COVID-19 is uncommon. Evidence suggest that in utero exposure to maternal influenza and SARS-CoV-2 infections may have a significant impact on the developing immune system with activation of both innate and adaptive responses, possibly related to placental inflammation. Here in, we review how maternal respiratory infections, associated with airway, systemic and placental inflammation but also changes in maternal microbiota might impact infant's immune responses after birth. The clinical impact of immune modifications observed following maternal respiratory infections remains unexplored. Given the high frequencies of respiratory infections during pregnancy (COVID-19, influenza but also RSV and HMPV), the impact on global child health could be important.
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