Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey.
Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey.
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DOI：
10.1371/journal.pone.0127451
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Gu A
中科院分区：
文献类型：
--
作者：
Xu C;Liu Q;Liu H;Héroux P;Zhang Q;Jiang ZY;Gu A
关于化学物质环境暴露对普通人群雄激素系统的影响，目前所知甚少。我们研究了全国健康与营养调查（2011-2012）中的5107名受试者。尿液、血清和血液中包含110种化学物质的15个亚类与血清睾酮水平的关系进行了分析。按睾酮中位数（374.51 ng/dL）分为睾酮高、低两组。在调整年龄、种族、可替宁、体重指数、肌酐、酒精和贫困收入比后，使用logistic回归估计与睾酮相关的单个化学物质的优势比（ORs）。成年男性尿扁豆酸和锶与低睾酮浓度之间的关系，暴露的最高和最低四分位数的调整ORs分别为2.12 （95% CI: 1.07, 4.21; Ptrend = 0.044）和1.84 （95% CI: 1.02, 3.34; Ptrend = 0.018）。然而，没有观察到其余化学物质与睾丸激素的关联。国家健康和营养检查调查数据表明，尿扁桃酸和锶水平的升高与成年男性血清睾酮水平低呈负相关。
Little is known regarding the effects of environmental exposure of chemicals on androgenic system in the general population. We studied 5,107 subjects included in the National Health and Nutrition Examination Survey (2011–2012). Urinary, serum, and blood levels of 15 subclasses comprising 110 individual chemicals were analyzed for their association with serum testosterone levels. The subjects were divided into high and low testosterone groups according to the median testosterone concentration (374.51 ng/dL). Odds ratios (ORs) of individual chemicals in association with testosterone were estimated using logistic regression after adjusting for age, ethnicity, cotinine, body mass index, creatinine, alcohol, and the poverty income ratio. Adjusted ORs for the highest versus lowest quartiles of exposure were 2.12 (95% CI: 1.07, 4.21; Ptrend = 0.044), 1.84 (95% CI: 1.02, 3.34; Ptrend = 0.018) for the association between urinary mandelic acid, and strontium quartiles with low testosterone concentrations in adult men, respectively. However, no association was observed for the remaining chemicals with testosterone. The National Health and Nutrition Examination Survey data suggest that elevations in urinary mandelic acid, and strontium levels are negatively related to low serum testosterone levels in adult men.
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影响因子：
6.1
作者：
Joensen, Ulla Nordstrom;Veyrand, Bruno;Jorgensen, Niels
通讯作者：
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影响因子：
10.4
作者：
Scinicariello F;Buser MC
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影响因子：
6.3
作者：
CAMPAGNA, D;MERGLER, D;DROLET, D
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DROLET, D
DOI：
10.1016/s1383-5718(03)00081-0
发表时间：
2003-06-06
影响因子：
1.9
作者：
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Migliore, L
影响因子：
10.4
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Joensen UN;Bossi R;Leffers H;Jensen AA;Skakkebaek NE;Jørgensen N
通讯作者：
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