Do perfluoroalkyl compounds impair human semen quality?
Do perfluoroalkyl compounds impair human semen quality?
复制标题
DOI：
10.1289/ehp.0800517
复制
发表时间：
2009-06
影响因子：
10.4
通讯作者：
Jørgensen N
中科院分区：
文献类型：
--
作者：
Joensen UN;Bossi R;Leffers H;Jensen AA;Skakkebaek NE;Jørgensen N
全氟烷基酸(PFAA)在全球野生动物和人类中都有发现，被怀疑是内分泌干扰物。此前没有关于丹麦成年男性PFAA水平的报道，也没有关于精液质量和PFAA暴露之间可能存在关联的报道。我们调查了PFAA和睾丸功能之间的可能联系。我们假设，较高的PFAA水平将与较低的精液质量和较低的睾酮水平相关。我们分析了10种不同的PFAA和生殖激素水平的血清样本，并从普通人群(中位年龄，19岁)中评估了105名丹麦男性的精液质量。全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)和全氟己烷磺酸在所有青年男性中都有相当高的水平(中位数分别为24.5、4.9和6.6 ng/mL)。全氟辛烷磺酸和全氟辛烷磺酸联合水平高的男性射精中正常精子的中位数为620万，而全氟辛烷磺酸-全氟辛酸水平低的男性为1550万(p=0.030)。此外，我们还发现，在全氟辛烷磺酸-全氟辛烷磺酸水平较高的男性中，精子密度降低、精子总数减少以及垂体-性腺激素改变的趋势并不显著。高水平的PFAA与较少的正常精子有关。因此，高水平的PFAA可能会导致年轻人经常出现的精液质量低下，这是无法解释的。然而，我们的发现需要在更大的研究中得到证实。
Perfluoroalkyl acids (PFAAs) are found globally in wildlife and humans and are suspected to act as endocrine disruptors. There are no previous reports of PFAA levels in adult men from Denmark or of a possible association between semen quality and PFAA exposure. We investigated possible associations between PFAAs and testicular function. We hypothesized that higher PFAA levels would be associated with lower semen quality and lower testosterone levels. We analyzed serum samples for levels of 10 different PFAAs and reproductive hormones and assessed semen quality in 105 Danish men from the general population (median age, 19 years). Considerable levels of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid were found in all young men (medians of 24.5, 4.9, and 6.6 ng/mL, respectively). Men with high combined levels of PFOS and PFOA had a median of 6.2 million normal spermatozoa in their ejaculate in contrast to 15.5 million among men with low PFOS–PFOA (p = 0.030). In addition, we found nonsignificant trends with regard to lower sperm concentration, lower total sperm counts, and altered pituitary–gonadal hormones among men with high PFOS–PFOA levels. High PFAA levels were associated with fewer normal sperm. Thus, high levels of PFAAs may contribute to the otherwise unexplained low semen quality often seen in young men. However, our findings need to be corroborated in larger studies.
登录
查看更多内容
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
10.4
作者：
Kärrman A;Ericson I;van Bavel B;Darnerud PO;Aune M;Glynn A;Lignell S;Lindström G
通讯作者：
Lindström G
影响因子：
--
作者：
Jensen, Allan Astrup;Leffers, Henrik
通讯作者：
Leffers, Henrik
影响因子：
5.4
作者：
Duty, SM;Silva, MJ;Hauser, R
通讯作者：
Hauser, R
影响因子：
11.4
作者：
Bossi, R;Riget, FF;Dietz, R
通讯作者：
Dietz, R