Vitamin D and risk of cognitive decline in elderly persons.
Vitamin D and risk of cognitive decline in elderly persons.
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DOI：
10.1001/archinternmed.2010.173
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发表时间：
2010-07-12
影响因子：
--
通讯作者：
Melzer, David
中科院分区：
文献类型：
--
作者：
Llewellyn, David J.;Lang, Iain A.;Langa, Kenneth M.;Muniz-Terrera, Graciela;Phillips, Caroline L.;Cherubini, Antonio;Ferrucci, Luigi;Melzer, David
据我们所知，还没有前瞻性研究检查维生素D与认知能力下降或痴呆症之间的关系。我们在1998年至2006年在意大利进行的InCHIANTI人群研究中确定了低水平的血清25-羟基维生素D（25[OH]D）是否与认知能力显著下降的风险增加相关，该研究每3年进行一次随访评估。共有858名65岁或以上的成年人完成了访谈、认知评估和体检，并提供了血液样本。使用简易精神状态检查（MMSE）评估认知下降，并将显著下降定义为3分或更多。还使用了跟踪制作测试A和B，并将显著下降定义为下降分布的最差10%或停止测试。与血清25（OH）D水平充足（≥75 nmol/L）的受试者相比，血清25（OH）D严重缺乏（水平<25 nmol/L）的受试者MMSE认知功能显著下降的多变量校正相对风险（95%置信区间[CI]）为1.60（95%CI，1.19-2.00）。多变量调整的随机效应模型表明，严重缺乏25（OH）D的参与者的评分比25（OH）D水平充足的参与者每年多下降0.3分。与25（OH）D水平充足的患者相比，25（OH）D严重缺乏的患者在连线试验B中显著下降的相对风险为1.31（95%CI，1.03-1.51）。没有观察到明显的相关性，为线索制作测试A。在一项为期6年的研究中，低水平的维生素D与老年人的认知能力大幅下降有关，这为治疗和预防提供了重要的新可能性。
To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia. We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population–based study conducted in Italy between 1998 and 2006 with follow-up assessments every 3 years. A total of 858 adults 65 years or older completed interviews, cognitive assessments, and medical examinations and provided blood samples. Cognitive decline was assessed using the Mini-Mental State Examination (MMSE), and substantial decline was defined as 3 or more points. The Trail-Making Tests A and B were also used, and substantial decline was defined as the worst 10% of the distribution of decline or as discontinued testing. The multivariate adjusted relative risk (95% confidence interval [CI]) of substantial cognitive decline on the MMSE in participants who were severely serum 25 (OH)D deficient (levels <25 nmol/L) in comparison with those with sufficient levels of 25(OH)D (≥75 nmol/L) was 1.60 (95% CI, 1.19-2.00). Multivariate adjusted random-effects models demonstrated that the scores of participants who were severely 25(OH)D deficient declined by an additional 0.3 MMSE points per year more than those with sufficient levels of 25(OH)D. The relative risk for substantial decline on Trail-Making Test B was 1.31 (95% CI, 1.03-1.51) among those who were severely 25(OH)D deficient compared with those with sufficient levels of 25(OH)D. No significant association was observed for Trail-Making Test A. Low levels of vitamin D were associated with substantial cognitive decline in the elderly population studied over a 6-year period, which raises important new possibilities for treatment and prevention.
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DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
11
作者：
Lee, David M.;Tajar, Abdelouahid;Wu, Frederick C. W.
通讯作者：
Wu, Frederick C. W.
影响因子：
4.2
作者：
Cherubini, A;Martin, A;Ferrucci, L
通讯作者：
Ferrucci, L
影响因子：
8.6
作者：
Newmark, Harold L.;Newmark, Jonathan
通讯作者：
Newmark, Jonathan
DOI：
10.1093/gerona/60.11.1414
发表时间：
2005-11-01
影响因子：
5.1
作者：
Maggio, D;Cherubini, A;Ferrucci, L
通讯作者：
Ferrucci, L