Micropatterned Surfaces for the Study of Cancer and Endothelial Cell Interactions with Hyaluronic Acid
Micropatterned Surfaces for the Study of Cancer and Endothelial Cell Interactions with Hyaluronic Acid
复制标题
用于研究癌症和内皮细胞与透明质酸相互作用的微图案表面
DOI：
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
S. Gerecht
中科院分区：
文献类型：
--
作者：
Courtney Smulovitz;Laura E. Dickinson;S. Gerecht
Hyaluronic acid (HA) is a glycosaminoglycan component of the extracellular matrix. Studies have shown that various cancers exhibit high levels of HA content, and that an increased amount of HA corresponds to poor patient prognosis. HA has been implicated in cellular interactions that are associated with cancer progression, including cell adhesion, motility, and differentiation. Micropatterned functional HA surfaces were developed to study interactions between cancer cells and HA. The adhesion and migration of cancer cells representing different stages of tumorigenesis were examined. A similar surface patterning approach was used to create HA regions next to fibronectin in two- and three-dimensional settings to visualize and study the interactions between cancer and endothelial cells. The ability to observe the dynamic interactions of cancer cells and angiogenesis within a HA-rich microenvironment will improve the fundamental understanding of cancer progression and contribute to the development of advanced therapeutic targets.
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影响因子：
3.4
作者：
Camci-Unal G;Aubin H;Ahari AF;Bae H;Nichol JW;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
6.2
作者：
Veiseh M;Breadner D;Ma J;Akentieva N;Savani RC;Harrison R;Mikilus D;Collis L;Gustafson S;Lee TY;Koropatnick J;Luyt LG;Bissell MJ;Turley EA
通讯作者：
Turley EA
影响因子：
6.1
作者：
Dickinson LE;Lütgebaucks C;Lewis DM;Gerecht S
通讯作者：
Gerecht S
影响因子：
20.3
作者：
Hanjaya-Putra, Donny;Bose, Vivek;Gerecht, Sharon
通讯作者：
Gerecht, Sharon
影响因子：
6.2
作者：
El-Dakdouki MH;Zhu DC;El-Boubbou K;Kamat M;Chen J;Li W;Huang X
通讯作者：
Huang X