Limb regeneration in axolotl: is it superhealing?
Limb regeneration in axolotl: is it superhealing?
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DOI：
10.1100/tsw.2006.324
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发表时间：
2006-05-05
影响因子：
--
通讯作者：
Lévesque M
中科院分区：
文献类型：
--
作者：
Roy S;Lévesque M
蝾螈的肢体再生能力几乎是传奇。事实上，像蝾螈这样的有尾目动物是唯一一种可以在一生中再生多种结构的脊椎动物，比如四肢、颌骨、尾巴、脊髓和皮肤（名单还在继续）。因此，令人惊讶的是，尽管我们已经知道它们的再生潜力超过200年，但我们对成人组织形态发生成就背后的机制知之甚少。在再生和其他学科如发育和伤口愈合之间可以得出许多观察结果。在这篇综述中，我们提出了功能分析的新进展，这将有助于解决特定基因在再生过程中的作用。我们还提出了一个伤口愈合和再生之间的相似性分析，并讨论是否蝾螈是超级愈合。更好地了解这些动物的再生能力可以通过为再生医学提供关于如何开发导致人类再生的治疗方法的方向而带来重大利益。
The ability of axolotls to regenerate their limbs is almost legendary. In fact, urodeles such as the axolotl are the only vertebrates that can regenerate multiple structures like their limbs, jaws, tail, spinal cord, and skin (the list goes on) throughout their lives. It is therefore surprising to realize, although we have known of their regenerative potential for over 200 years, how little we understand the mechanisms behind this achievement of adult tissue morphogenesis. Many observations can be drawn between regeneration and other disciplines such as development and wound healing. In this review, we present new developments in functional analysis that will help to address the role of specific genes during the process of regeneration. We also present an analysis of the resemblance between wound healing and regeneration, and discuss whether axolotls are superhealers. A better understanding of these animals' regenerative capacity could lead to major benefits by providing regenerative medicine with directions on how to develop therapeutic approaches leading to regeneration in humans.
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影响因子：
56.9
作者：
FRENCH, V;BRYANT, PJ;BRYANT, SV
通讯作者：
BRYANT, SV
影响因子：
2.7
作者：
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通讯作者：
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2.7
作者：
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通讯作者：
NAMENWIRTH, M