Effects of Sleep Deprivation on Working Memory: Change in Functional Connectivity Between the Dorsal Attention, Default Mode, and Fronto-Parietal Networks.
Effects of Sleep Deprivation on Working Memory: Change in Functional Connectivity Between the Dorsal Attention, Default Mode, and Fronto-Parietal Networks.
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睡眠剥夺对工作记忆的影响：背注意，默认模式和额叶网络之间的功能连通性变化。
DOI：
10.3389/fnhum.2020.00360
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发表时间：
2020
影响因子：
2.9
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Dai C;Zhang Y;Cai X;Peng Z;Zhang L;Shao Y;Wang C
睡眠剥夺(SD)在现代社会中非常普遍，对认知功能特别是工作记忆(WM)有深远的影响。这种类型的内存是完成许多任务所必需的，并且受到SD的不利影响。然而，SD影响WM的认知神经机制仍不清楚。在这项研究中，我们研究了SD后WM所涉及的脑网络的变化。22名健康受试者在静息清醒状态下进行功能磁共振成像扫描，并在总扫描36h后再次进行功能磁共振成像扫描，并在每次扫描前执行WM任务。选择默认模式网络(DMN)、背侧注意网络(DAN)、额顶网络(FPN)、突显网络(SN)等19个主节点进行脑网络连接的功能分析。计算种子区域之间的功能连通性测量，以进行感兴趣区域(ROI)到ROI的分析，并确定ROI到ROI的连通性模式。然后，通过皮尔逊相关分析来检验大脑网络中功能连通性的显着变化与工作记忆成绩之间的关系。工作记忆绩效在SD后显著下降。与清醒状态相比，SD后DAN和DMN之间的功能连接性显著增加，而FPN和DMN之间的功能连接性显著降低。相关分析显示，DAN和DMN之间的功能连接性增强与WM成绩的下降呈负相关，而FPN和DMN之间的功能连接性的下降与WM成绩的下降呈正相关。这些发现提示SD可能通过改变DMN、DAN和FPN之间的功能连接来影响WM。
Sleep deprivation (SD) is very common in modern society and has a profound effect on cognitive function, in particular on working memory (WM). This type of memory is required for completion of many tasks and is adversely affected by SD. However, the cognitive neural mechanism by which SD affects WM, remains unclear. In this study, we investigated the changes in the brain network involved in WM after SD. Twenty-two healthy subjects underwent functional magnetic resonance imaging scan while in a state of resting wakefulness and again after 36 h of total SD and performed a WM task before each scanning session. Nineteen main nodes of the default mode network (DMN), dorsal attention network (DAN), fronto-parietal network (FPN), salience network (SN), and other networks were selected for functional analysis of brain network connections. Functional connectivity measures were computed between seed areas for region of interest (ROI)-to-ROI analysis and to identify patterns of ROI-to-ROI connectivity. The relationship between the significant changes in functional connectivity in the brain network and WM performance were then examined by Pearson’s correlation analysis. WM performance declined significantly after SD. Compared with the awake state, the functional connectivity between DAN and DMN significantly increased after SD while that between FPN and DMN significantly decreased. Correlation analysis showed that the enhanced functional connectivity between DAN and DMN was negatively correlated with the decline in WM performance and that the decline in functional connectivity between FPN and DMN was positively correlated with decreased WM performance. These findings suggested that SD may affect WM by altering the functional connectivity among DMN, DAN, and FPN.
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影响因子：
5.7
作者：
De Havas, Jack A.;Parimal, Sarayu;Chee, Michael W. L.
通讯作者：
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