Seroprevalence and risk factors for Toxoplasmosis in HIV infected and non-infected individuals in Bahir Dar, Northwest Ethiopia.
Seroprevalence and risk factors for Toxoplasmosis in HIV infected and non-infected individuals in Bahir Dar, Northwest Ethiopia.
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埃塞俄比亚西北部巴希尔·达（Bahir Dar）感染HIV和未感染个体的毒质量的血清阳性和危险因素。
DOI：
10.1186/1756-3305-6-15
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发表时间：
2013-01-16
影响因子：
3.2
通讯作者：
Kassa T
中科院分区：
文献类型：
--
作者：
Walle F;Kebede N;Tsegaye A;Kassa T
弓形虫病是一种分布在世界各地的人畜共患疾病，是由普遍存在的细胞内原虫弓形虫引起的一种感染。这是一个重大的公共卫生问题，因为这种疾病在艾滋病毒疾病患者的死亡率或身体和/或心理后遗症方面很严重。本研究的目的是评估在埃塞俄比亚西北部Bahir Dar的Felege Hiwot转诊医院就诊的HIV感染者和非感染者中弓形虫IgG和IgM抗体的血清阳性率及相关危险因素。在阿姆哈拉民族地区州Bahir Dar的Felege Hiwot转诊医院进行了一项横断面研究。在费利格·希沃特转诊医院收集了103名艾滋病毒感染前抗逆转录病毒治疗患者的静脉血样本，并在血库收集了101名艾滋病毒阴性、表面健康的自愿献血者的静脉血样本。使用市售ELISA试剂盒分析血清样本抗刚地弓形虫IgG和IgM抗体。同时获取每个个体的社会人口学和相关弓形虫病危险因素，并使用SPSS版本18对数据进行分析。在HIV血清阳性人群中，抗t阳性分别占87.4%（90/103）和10.7%（11/103）。弓形虫IgG和IgM抗体。多因素logistic回归分析显示，抗t。弓形虫血清阳性与HIV阳性个体未煮熟或生肉消费（调整后的or =5.73, 95% CI=1.35-24.39； P=0.02）和接触猫（调整后的or = 4.29, 95% CI=1.08-16.94； P=0.04）独立显著相关。在HIV阴性的健康献血者中，抗t抗体的流行。IgG和IgM抗体阳性率分别为70.29%和2.97%。多因素分析显示，未煮熟或生肉消费（调整后or =6.45, 95% CI=2.16-19.28; p=0.001）和性别（or =6.79, 95% CI=2.14-21.60; p=0.001）与抗t抗体有独立的显著相关。弓形虫IgG血清阳性，男性感染人数明显高于女性。目前的研究结果显示，血清中抗t抗体的流行率很高。在Bahir Dar，艾滋病毒感染的抗逆转录病毒治疗前和未感染艾滋病毒的明显健康献血者体内的弓形虫抗体。在接受抗逆转录病毒治疗前感染艾滋病毒的献血者和未感染艾滋病毒的显然健康的献血者中，食用未煮熟的或生肉可能在很大程度上导致感染弓形虫。可能适当包括常规血清学筛选试验，以确定抗t。HIV感染前抗逆转录病毒治疗个体和HIV阴性明显健康献血者体内的弓形虫抗体。此外，建议进行健康教育，避免食用未煮熟的肉类和生肉，避免与猫接触。
Toxoplasmosis, a zoonotic disease distributed worldwide, is an infection caused by the ubiquitous obligatory intracellular coccidian protozoan organism, Toxoplasma gondii. It is a major public health concern because the disease is serious in terms of mortality or physical and /or psychological sequellae in patients with HIV disease. The aim of the study was to assess the seroprevalence of Toxoplasma gondii IgG and IgM antibodies and associated risk factors in HIV infected and non-infected individuals attending Felege Hiwot referral hospital, Bahir Dar, Northwest Ethiopia. A cross sectional study was conducted at Felege Hiwot referral hospital, Bahir Dar, Amhara National Regional State. Venous blood samples were collected from 103 HIV infected pre anti-retroviral therapy patients at Felege Hiwot referral hospital and 101 HIV negative apparently healthy voluntary blood donors at the blood bank. Serum samples were analyzed for anti-Toxoplasma gondii IgG and IgM antibodies using a commercially available ELISA kit. Socio-demographic and associated risk factors for Toxoplasmosis from each individual were also obtained and the data was analyzed using SPSS version 18. Of the examined HIV seropositive individuals, 87.4% (90/103) and 10.7% (11/103) were positive for anti-T. gondii IgG and IgM antibodies, respectively. Multivariate analysis using logistic regression showed that anti-T. gondii seropositivity was independently significantly associated with undercooked or raw meat consumption (adjusted OR=5.73, 95% CI=1.35-24.39; P=0.02) and having contact with cat (adjusted OR= 4.29, 95% CI=1.08-16.94; P=0.04) in HIV positive individuals. In HIV negative apparently healthy blood donors, prevalence of anti-T. gondii antibodies were 70.29% and 2.97% for IgG and IgM, respectively. Multivariate analysis showed that undercooked or raw meat consumption (adjusted OR=6.45, 95% CI=2.16-19.28; p=0.001) and sex (OR=6.79, 95% CI=2.14-21.60; p=0.001) were independently significantly associated with anti-T. gondii IgG seropositivity, with a significantly higher number of males affected than females. The present findings showed a high sero-prevalence of anti-T. gondii antibodies in HIV infected pre-ART and HIV non-infected apparently healthy blood donors in Bahir Dar. Consumption of undercooked or raw meat might greatly contribute towards acquiring T. gondii infection in HIV infected pre-ART and HIV non-infected apparently healthy blood donors. It may be appropriate to include routine serological screening test for determination of anti-T. gondii antibodies in HIV infected pre-ART individuals and HIV negative apparently healthy blood donors. In addition, health education towards avoiding eating undercooked and raw meat, and avoiding contact with cats were recommended.
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影响因子：
4.5
作者：
Ertug S;Okyay P;Turkmen M;Yuksel H
通讯作者：
Yuksel H
影响因子：
2.4
作者：
Flegr, J;Zitkova, S;Frynta, D
通讯作者：
Frynta, D
影响因子：
5
作者：
Jones, JL;Kruszon-Moran, D;McAuley, JB
通讯作者：
McAuley, JB
影响因子：
3.7
作者：
Alvarado-Esquivel, Cosme;Mercado-Suarez, Miguel Francisco;Martinez-Garcia, Sergio Arturo
通讯作者：
Martinez-Garcia, Sergio Arturo
DOI：
10.1590/s0074-02762002000400001
发表时间：
2002-06-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Ferreira, Marcelo Simão;Borges, Aércio Sebastião
通讯作者：
Borges, Aércio Sebastião