Overexpression of Testes-Specific Protease 50 (TSP50) Predicts Poor Prognosis in Patients with Gastric Cancer.
Overexpression of Testes-Specific Protease 50 (TSP50) Predicts Poor Prognosis in Patients with Gastric Cancer.
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睾丸特异性蛋白酶50（TSP50）的过表达预测胃癌患者的预后不良。
DOI：
10.1155/2014/498246
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发表时间：
2014
影响因子：
2
通讯作者：
Luo R
中科院分区：
文献类型：
--
作者：
Liu F;Cao Q;Liu N;Li C;You C;Liu C;Xue L;Luo R
目的.探讨TSP 50蛋白在胃癌组织中的表达及其与临床预后的关系。 方法.对334例原发性胃癌组织芯片（TMA）进行TSP 50免疫组化（IHC）分析。Western blot检测胃癌组织中TSP 50的表达。结果免疫组化结果显示，57.2%的人胃癌组织中有191例（191/334）呈高表达。而在20例癌旁组织中均呈弱表达。Western blot证实了这一点，表明TSP 50在胃癌组织中的表达水平显著高于癌旁组织。高水平的TSP 50与临床病理特征之间存在显著相关性，包括手术年龄小（P = 0.001）、TNM分期晚（P = 0.000）和淋巴结转移（P = 0.003）。TSP 50高表达胃癌患者的生存期明显短于TSP 50低表达者（P = 0.021）。多因素考克斯回归分析显示，TSP 50过表达是影响胃癌患者预后的独立因素（P = 0.017）。结论.我们的数据表明，TSP 50蛋白表达升高可能是胃癌患者预后不良的潜在预测因素。
Purpose. To investigate the expression of TSP50 protein in human gastric cancers and its correlation with clinical/prognostic significance. Methods. Immunohistochemistry (IHC) analysis of TSP50 was performed on a tissue microarray (TMA) containing 334 primary gastric cancers. Western blot was carried out to confirm the expression of TSP50 in gastric cancers. Results. IHC analysis revealed high expression of TSP50 in 57.2% human gastric cancer samples (191 out of 334). However, it was poorly expressed in all of the 20 adjacent nontumor tissues. This was confirmed by western blot, which showed significantly higher levels of TSP50 expression in gastric cancer tissues than adjacent nontumor tissues. A significant association was found between high levels of TSP50 and clinicopathological characteristics including junior age at surgery (P = 0.001), later TNM stage (P = 0.000), and present lymph node metastases (P = 0.003). The survival of gastric cancer patients with high expression of TSP50 was significantly shorter than that of the patients with low levels of TSP50 (P = 0.021). Multivariate Cox regression analysis indicated that TSP50 overexpression was an independent prognostic factor for gastric cancer patients (P = 0.017). Conclusions. Our data demonstrate that elevated TSP50 protein expression could be a potential predictor of poor prognosis in gastric cancer patients.
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影响因子：
4.1
作者：
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通讯作者：
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