MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
复制标题
DOI：
10.3389/fimmu.2018.02232
复制
发表时间：
2018
影响因子：
7.3
通讯作者：
McKenzie ANJ
中科院分区：
文献类型：
--
作者：
Knolle MD;Chin SB;Rana BMJ;Englezakis A;Nakagawa R;Fallon PG;Git A;McKenzie ANJ
第2组先天性淋巴样细胞（ILC 2）主要通过产生2型细胞因子IL-5、IL-9和IL-13在2型免疫应答的启动和维持中起关键作用。ILC 2对于有效消除蠕虫寄生虫至关重要，但也有助于引起哮喘和过敏等疾病的有害的2型免疫反应。虽然已经确定了几个转录因子，调节ILC 2的发展和功能，很少有人知道的转录后机制，调节这些过程。我们鉴定了来自暴露于两种不同刺激的小鼠的ILC 2中协同调节的微小RNA（miRNA），所述刺激即IL-33“alarmin”施用或巴西日本圆线虫寄生虫感染。miR-155在ILC 2中响应于两种刺激而上调，并且miR-155−/−小鼠具有受损的IL-33驱动的ILC 2应答。使用混合骨髓嵌合体，我们证明这种缺陷是ILC 2固有的，并且miR-155保护ILC 2免于凋亡，同时对ILC 2增殖或细胞因子产生几乎没有影响。这些数据揭示了在ILC 2活化后受调控的miRNA的子集，并确立了miR-155在活化后调控ILC 2存活中的特异性作用。
Group-2 innate lymphoid cells (ILC2) play critical roles in the initiation and maintenance of type-2 immune responses, predominantly through their production of the type-2 cytokines IL-5, IL-9, and IL-13. ILC2 are essential for the efficient elimination of helminth parasites, but also contribute to the detrimental type-2 immune responses that underlie diseases such as asthma and allergy. While several transcription factors have been identified that regulate the development and function of ILC2, less is known about the post-transcriptional mechanisms that regulate these processes. We identified micro-RNAs (miRNAs) that are co-ordinately regulated in ILC2 from mice exposed to two different stimuli, namely IL-33 “alarmin” administration or Nippostrongylus brasiliensis parasitic worm infection. miR-155 is upregulated in ILC2 in response to both stimuli and miR-155−/− mice had impaired IL-33-driven ILC2 responses. Using mixed bone marrow chimeras, we demonstrate that this deficit is intrinsic to ILC2 and that miR-155 protects ILC2 from apoptosis, while having little impact on ILC2 proliferation or cytokine production. These data reveal a subset of miRNAs that are regulated upon ILC2 activation and establish a specific role for miR-155 in regulating ILC2 survival following activation.
登录
查看更多内容
影响因子：
4.5
作者：
Liu S;Sawada T;Lee S;Yu W;Silverio G;Alapatt P;Millan I;Shen A;Saxton W;Kanao T;Takahashi R;Hattori N;Imai Y;Lu B
通讯作者：
Lu B
影响因子：
32.4
作者：
O'Connell RM;Kahn D;Gibson WS;Round JL;Scholz RL;Chaudhuri AA;Kahn ME;Rao DS;Baltimore D
通讯作者：
Baltimore D
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
DOI：
10.1038/nrm3999
发表时间：
2015-06
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Fuchs Y;Steller H
通讯作者：
Steller H
DOI：
10.1016/j.jaci.2014.11.037
发表时间：
2015-07
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Christianson CA;Goplen NP;Zafar I;Irvin C;Good JT Jr;Rollins DR;Gorentla B;Liu W;Gorska MM;Chu H;Martin RJ;Alam R
通讯作者：
Alam R