Cellular and molecular mechanisms of antifungal innate immunity at epithelial barriers: The role of C-type lectin receptors.
Cellular and molecular mechanisms of antifungal innate immunity at epithelial barriers: The role of C-type lectin receptors.
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DOI：
10.1002/eji.201848054
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发表时间：
2020-03
影响因子：
5.4
通讯作者：
中科院分区：
文献类型：
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人类经常暴露于真菌，无论是在上皮屏障的真菌或吸入孢子的形式。由于模式识别受体的表达，先天免疫细胞在维持免疫关系和预防皮肤、粘膜或全身性真菌感染中起关键作用，所述模式识别受体识别真菌细胞壁组分并调节其活化状态和随后的适应性免疫应答。共生真菌在调节上皮屏障的稳态和疾病易感性方面也起关键作用。本文将概述抗真菌先天免疫的细胞和分子机制，重点是C型凝集素受体及其相关性的背景下，宿主真菌相互作用在皮肤和粘膜表面的小鼠实验模型，以及患者易受真菌感染。C型凝集素受体（C-type lectin receptor，C-Lectin）介导的上皮屏障处的先天免疫细胞对真菌的识别可防止真菌感染复发，并建立宿主-真菌共生关系。这些概念已经在小鼠模型和患有影响CLR（例如dectin-1）或其信号传导分子（例如CARD 9）的功能的原发性免疫缺陷的患者中得到证实。
Humans are constantly exposed to fungi, either in the form of commensals at epithelial barriers or inhaled spores. Innate immune cells play a pivotal role in maintaining commensal relationships and preventing skin, mucosal or systemic fungal infections due to the expression of pattern recognition receptors that recognize fungal cell wall components and modulate both their activation status and the ensuing adaptive immune response. Commensal fungi also play critical role in the modulation of homeostasis and disease susceptibility at epithelial barriers. This review will outline cellular and molecular mechanisms of anti-fungal innate immunity focusing on C-type lectin receptors and their relevance in the context of host-fungi interactions at skin and mucosal surfaces in murine experimental models as well as patients susceptible to fungal infections. C-type lectin receptor (CLR)-mediated recognition of fungi by innate immune cells at the epithelial barriers prevents recurrent fungal infections and establishes host-fungi commensal relationships. These concepts have been demonstrated in mouse models and patients with primary immunodeficiencies affecting the function of CLRs (e.g. dectin-1) or their signaling molecules (e.g. CARD9).
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影响因子：
5.5
作者：
Bendickova, Kamila;Tidu, Federico;Fric, Jan
通讯作者：
Fric, Jan
影响因子：
7.3
作者：
Drummond RA;Franco LM;Lionakis MS
通讯作者：
Lionakis MS
影响因子：
6.7
作者：
Altmeier S;Toska A;Sparber F;Teijeira A;Halin C;LeibundGut-Landmann S
通讯作者：
LeibundGut-Landmann S
影响因子：
5.5
作者：
Cheng SC;van de Veerdonk FL;Lenardon M;Stoffels M;Plantinga T;Smeekens S;Rizzetto L;Mukaremera L;Preechasuth K;Cavalieri D;Kanneganti TD;van der Meer JW;Kullberg BJ;Joosten LA;Gow NA;Netea MG
通讯作者：
Netea MG
影响因子：
64.8
作者：
通讯作者：
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