Meninges: A Widespread Niche of Neural Progenitors for the Brain.
Meninges: A Widespread Niche of Neural Progenitors for the Brain.
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DOI：
10.1177/1073858420954826
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Bifari F
中科院分区：
文献类型：
--
作者：
Decimo I;Dolci S;Panuccio G;Riva M;Fumagalli G;Bifari F
新的证据强调了脑膜在相关大脑功能中发挥的多种作用，因为它们是大脑的保护膜，产生和释放对神经细胞迁移和存活很重要的几种营养因子，控制脑脊液动力学，并包含影响神经实质功能的众多免疫相互作用。此外，不同的研究小组已经确定了包括人类在内的不同哺乳动物物种在发育期间和成年期脑膜中存在的神经祖细胞亚群。有趣的是，这些未成熟的神经细胞能够从脑膜迁移到神经实质，并分化成功能性皮质神经元或少突胶质细胞。脑膜中的未成熟神经细胞会迅速对脑部疾病做出反应。在实验性脱髓鞘、创伤性脊髓和脑损伤、杏仁核损伤、中风和进行性共济失调后，观察到损伤引起的脑膜神经祖细胞的扩张和迁移。在这篇综述中，我们总结了脑膜作为干细胞生态位的功能以及脑膜中未成熟神经细胞的存在的数据，并讨论了它们在大脑健康和疾病中的作用。此外，我们考虑利用脑膜神经祖细胞进行再生医学来治疗神经系统疾病。
Emerging evidence highlights the several roles that meninges play in relevant brain functions as they are a protective membrane for the brain, produce and release several trophic factors important for neural cell migration and survival, control cerebrospinal fluid dynamics, and embrace numerous immune interactions affecting neural parenchymal functions. Furthermore, different groups have identified subsets of neural progenitors residing in the meninges during development and in the adulthood in different mammalian species, including humans. Interestingly, these immature neural cells are able to migrate from the meninges to the neural parenchyma and differentiate into functional cortical neurons or oligodendrocytes. Immature neural cells residing in the meninges promptly react to brain disease. Injury-induced expansion and migration of meningeal neural progenitors have been observed following experimental demyelination, traumatic spinal cord and brain injury, amygdala lesion, stroke, and progressive ataxia. In this review, we summarize data on the function of meninges as stem cell niche and on the presence of immature neural cells in the meninges, and discuss their roles in brain health and disease. Furthermore, we consider the potential exploitation of meningeal neural progenitors for the regenerative medicine to treat neurological disorders.
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DOI：
10.1093/cercor/bhy082
发表时间：
2018-07-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Barber M;Andrews WD;Memi F;Gardener P;Ciantar D;Tata M;Ruhrberg C;Parnavelas JG
通讯作者：
Parnavelas JG
影响因子：
11.8
作者：
Chau KF;Springel MW;Broadbelt KG;Park HY;Topal S;Lun MP;Mullan H;Maynard T;Steen H;LaMantia AS;Lehtinen MK
通讯作者：
Lehtinen MK
影响因子：
16.6
作者：
Dieni CV;Panichi R;Aimone JB;Kuo CT;Wadiche JI;Overstreet-Wadiche L
通讯作者：
Overstreet-Wadiche L
影响因子：
16.2
作者：
Choe Y;Siegenthaler JA;Pleasure SJ
通讯作者：
Pleasure SJ
影响因子：
5.3
作者：
Choe, Youngshik;Huynh, Trung;Pleasure, Samuel J.
通讯作者：
Pleasure, Samuel J.