The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology.
The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology.
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幽闭神经回路之谜及其在神经退行性病变中作用的最新进展。
DOI：
10.1186/s12993-021-00181-1
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发表时间：
2021-07-07
期刊：
影响因子：
--
通讯作者：
Aliev G
中科院分区：
文献类型：
--
作者：
Nikolenko VN;Rizaeva NA;Beeraka NM;Oganesyan MV;Kudryashova VA;Dubovets AA;Borminskaya ID;Bulygin KV;Sinelnikov MY;Aliev G
屏状核是一个参与形成几个皮质和皮质下神经微回路的结构，这些神经微回路可能参与意识感觉和奖励行为等功能。屏状核被认为是一个多模态的信息处理网络。屏状体的病理学见于某些神经系统疾病。到目前为止，还没有足够的全面的研究，包含准确的信息，参与屏状核在神经系统疾病的发展。本文综述了屏状核的解剖学、个体发育、细胞结构、神经网络及其与神经系统疾病发生的关系。使用Google Scholar、PubMed、NCBI MedLine和eLibrary数据库进行文献综述。尽管新的方法使人们有可能在分子，遗传和表观遗传水平上研究屏状体，但其功能和连接仍然知之甚少。的解剖位置，相对统一的细胞结构，和巨大的网络连接表明屏状体在整合和处理输入信息和形成连贯的看法不同的作用。几项研究已经表明，在神经退行性疾病，如帕金森病（PD），阿尔茨海默病（AD），自闭症，精神分裂症和抑郁症的屏状体的外观，结构和体积的变化。考虑到屏状体的结构，个体发育和功能，这篇文献综述提供了深入了解这个结构在大脑功能和行为中的关键作用。
The claustrum is a structure involved in formation of several cortical and subcortical neural microcircuits which may be involved in such functions as conscious sensations and rewarding behavior. The claustrum is regarded as a multi-modal information processing network. Pathology of the claustrum is seen in certain neurological disorders. To date, there are not enough comprehensive studies that contain accurate information regarding involvement of the claustrum in development of neurological disorders. Our review aims to provide an update on claustrum anatomy, ontogenesis, cytoarchitecture, neural networks and their functional relation to the incidence of neurological diseases. A literature review was conducted using the Google Scholar, PubMed, NCBI MedLine, and eLibrary databases. Despite new methods that have made it possible to study the claustrum at the molecular, genetic and epigenetic levels, its functions and connectivity are still poorly understood. The anatomical location, relatively uniform cytoarchitecture, and vast network of connections suggest a divergent role of the claustrum in integration and processing of input information and formation of coherent perceptions. Several studies have shown changes in the appearance, structure and volume of the claustrum in neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), autism, schizophrenia, and depressive disorders. Taking into account the structure, ontogenesis, and functions of the claustrum, this literature review offers insight into understanding the crucial role of this structure in brain function and behavior.
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影响因子：
3.2
作者：
Arrigo, Alessandro;Calamuneri, Alessandro;Quartarone, Angelo
通讯作者：
Quartarone, Angelo
DOI：
10.1007/bf00305558
发表时间：
1982-01-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
BRAAK, H;BRRAK, E
通讯作者：
BRRAK, E
影响因子：
2.5
作者：
Atlan, Gal;Terem, Anna;Citri, Ami
通讯作者：
Citri, Ami
影响因子：
2.6
作者：
Bickel, Stephan;Parvizi, Josef
通讯作者：
Parvizi, Josef
影响因子：
3
作者：
Hinova-Palova, Dimka V.;Edelstein, Lawrence;Ovtscharoff, Wladimir
通讯作者：
Ovtscharoff, Wladimir