The Sources of Parent-Child Transmission of Risk for Suicide Attempt and Deaths by Suicide in Swedish National Samples.
The Sources of Parent-Child Transmission of Risk for Suicide Attempt and Deaths by Suicide in Swedish National Samples.
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DOI：
10.1176/appi.ajp.2020.20010017
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发表时间：
2020-10-01
期刊：
影响因子：
--
通讯作者：
Edwards AC
中科院分区：
文献类型：
--
作者：
Kendler KS;Ohlsson H;Sundquist J;Sundquist K;Edwards AC
To clarify the sources of parent-offspring transmission for suicide attempt (SA) and suicide death (SD). Three sources of parent-child resemblance (genes+rearing, genes only and rearing only) are examined in parents and offspring from 4 family types from Swedish national samples: intact, not-lived-with biological father, lived with stepfather, and adoptive. Parent-offspring resemblance was assessed primarily by tetrachoric correlation. For SA→SA transmission, best estimate tetrachoric correlations (± 95% CIs) for genes+rearing, genes only and rearing only, were, respectively, +0.23 (0.23–0.24), +0.13 (0.11–0.15) and +0.14 (0.11–0.16). SA was more strongly transmitted to sons than daughters. Parental psychiatric disorders accounted for 40% of the genetic transmission but had no impact on rearing effects. For SD→SD transmission, best estimates of tetrachoric correlations for genes+rearing, genes only and rearing only cross-generational transmission were, respectively: + 0.16 (0.15–0.18), +0.07 (0.02–0.12) and −0.05 (−0.17–0.07). Although the SA-SD genetic correlation was high (+0.84), we could reject the hypothesis that they reflected behaviors only differing in severity on the same continuum of genetic liability. The transmission across generations of SA is moderately strong and arises equally from genetic and rearing effects. Parental psychiatric illness explains almost half of the genetic transmission of SA but none of the rearing effect. SD is modestly transmitted across generations, probably via genetic effects although rearing may play a role. While SA and SD share a substantial proportion of their hereditary risk, they do not, from a genetic perspective, simply reflect milder and more severe forms of the same diathesis.
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影响因子：
6.9
作者：
von Borczyskowski, A.;Lindblad, F.;Hjern, A.
通讯作者：
Hjern, A.
影响因子：
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作者：
Petersen L;Sørensen TI;Andersen PK;Mortensen PB;Hawton K
通讯作者：
Hawton K
DOI：
10.1097/00004583-200111000-00010
发表时间：
2001-11-01
影响因子：
13.3
作者：
Glowinski, AL;Bucholz, KK;Heath, AC
通讯作者：
Heath, AC
影响因子：
10.5
作者：
Linsley, KR;Schapira, K;Kelly, TP
通讯作者：
Kelly, TP
遗传对自杀和非致命自杀行为的影响：双胞胎研究结果。
DOI：
10.1016/j.eurpsy.2009.12.008
发表时间：
2010-06
期刊：
European psychiatry : the journal of the Association of European Psychiatrists
影响因子：
--
作者：
Pedersen NL;Fiske A
通讯作者：
Fiske A