Transactions Between Substance Use Intervention, the Oxytocin Receptor (OXTR) Gene, and Peer Substance Use Predicting Youth Alcohol Use.
Transactions Between Substance Use Intervention, the Oxytocin Receptor (OXTR) Gene, and Peer Substance Use Predicting Youth Alcohol Use.
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DOI：
10.1007/s11121-017-0749-5
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Vandenbergh DJ
中科院分区：
文献类型：
--
作者：
Cleveland HH;Griffin AM;Wolf PSA;Wiebe RP;Schlomer GL;Feinberg ME;Greenberg MT;Spoth RL;Redmond C;Vandenbergh DJ
This study investigated the Oxytocin Receptor gene’s (OXTR) moderation of associations between exposure to a substance misuse intervention, average peer substance use, and adolescents’ own alcohol use during the 9th grade. OXTR genetic risk was measured using five Single Nucleotide Polymorphisms (SNPs) and peer substance use was based on youths’ nominated closest friends’ own reports of alcohol, cigarette and marijuana use, based on data from the PROSPER Project. Regression models revealed several findings. First, low OXTR risk was linked to affiliating with friends who reported less substance use in the intervention condition but not the control condition. Second, affiliating with high substance-using friends predicted youth alcohol risk regardless of OXTR risk or intervention condition. Third, although high OXTR risk youth in the intervention condition who associated with low substance-using friends reported somewhat higher alcohol use than comparable youth in the control group, the absolute level of alcohol use among these youth was still among the lowest in the sample.
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