The association between obesity and GERD: a review of the epidemiological evidence.
The association between obesity and GERD: a review of the epidemiological evidence.
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DOI：
10.1007/s10620-008-0413-9
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发表时间：
2008-09
影响因子：
3.1
通讯作者：
El-Serag, Hashem
中科院分区：
文献类型：
--
作者：
El-Serag, Hashem
目前肥胖和胃食管反流病（GERD）相关疾病的流行，包括症状、食管糜烂、巴雷特食管（BE）和食管腺癌，引起了人们对研究这两种疾病之间关系的极大兴趣。多个病例对照和队列研究的结果表明，肥胖满足了与胃食管反流及其一些并发症的因果关系的几个标准，包括与胃食管反流症状、糜烂性食管炎和食管腺癌的普遍一致的关联。研究表明，体重增加但体重指数（BMI）仍在正常范围内的个体会出现胃反流症状的增加，这为BMI增加与胃反流增加之间可能存在剂量-反应关系提供了流行病学证据。然而，关于BE和肥胖之间关系的数据不太清楚，最近的调查显示几乎没有关联。然而，当单独考虑时，腹部肥胖似乎可以解释与胃反流（包括BE）相关的相当一部分。总体而言，流行病学数据显示，保持正常的BMI可以降低发生胃反流及其潜在并发症的可能性。
The current epidemics of obesity and gastroesophageal reflux disease (GERD)–related disorders, including symptoms, esophageal erosions, Barrett’s esophagus (BE), and esophageal adenocarcinoma, have generated much interest in studying the association between these two conditions. Results of multiple case-control and cohort studies indicate that obesity satisfies several criteria for a causal association with GERD and some of its complications, including a generally consistent association with GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma. An increase in GERD symptoms has been shown to occur in individuals who gain weight but continue to have a body mass index (BMI) in the normal range, contributing to the epidemiological evidence for a possible dose-response relationship between increasing BMI and increasing GERD. However, data are less clear on the relationship between BE and obesity, with more recent investigations showing little association. However, when considered separately, abdominal obesity seems to explain a considerable part of the association with GERD, including BE. Overall, epidemiological data show that maintaining a normal BMI may reduce the likelihood of developing GERD and its potential complications.
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